A Randomized Clinical Trial to Measure the Erosion Protection Benefits of a Novel Stabilized Stannous Fluoride Dentifrice versus a Control Dentifrice.

OBJECTIVES

The aim of this investigation was to assess the erosion protection ability of a novel stabilized stannous fluoride (SnF2) dentifrice and a control sodium fluoride dentifrice (NaF) using a well-credentialed human in situ model.

METHODS

A novel smooth texture 0.454% stabilized SnF2 dentifrice (Crest® Pro-Health™ smooth formula) and a 0.23% NaF marketed control dentifrice with 5% potassium nitrate (Sensodyne® Pronamel®) were compared in a 10-day, single center, randomized, controlled, double-blind, two-treatment, three-period crossover in situ clinical trial. Subjects wore a mandibular buccal appliance fitted with eight enamel specimens for approximately six hours over the course of each study day. Twice daily, subjects brushed the lingual surfaces of their teeth for 30 seconds while wearing the appliance, then swished with their assigned treatment toothpaste slurry for 90 seconds under the supervision of clinic staff. Erosive acid challenges with a citric acid-containing beverage (commercial orange juice) were done four times each day.

RESULTS

The SnF2 dentifrice provided 26.9% greater erosion protection relative to the NaF dentifrice at Day 10 (p < 0.03). Adjusted means of enamel surface loss at Day 10 were 9.117 µm for the SnF2 dentifrice and 12.471 µm for the NaF marketed control.

CONCLUSIONS

These results demonstrate the stabilized SnF2 dentifrice offered greater protection over the NaF dentifrice against the initiation and progression of dental erosion.