Zhao Xinyi, He Tao, He Yanyan, Chen Haijing
Oral Health Prev Dent. 2020 Jul 24;18(3):619-624. doi: 10.3290/j.ohpd.a44926.
The in-situ efficacy of an experimental stannous (Sn)-containing sodium fluoride (NaF) dentifrice against erosion and erosive tooth wear was compared with a conventional NaF dentifrice.
This was a randomised, controlled, double-blind, parallel-group clinical trial. Mandibular appliances containing four enamel specimens (2 per side [L/R] of the appliance) were worn by 60 generally healthy adult subjects. Subjects were randomised to treatment based on age and gender. Treatments included a Sn-containing NaF or conventional NaF dentifrice. Conditions of erosion (dentifrice slurry treatment) and erosion/tooth wear (dentifrice slurry plus brushing) were compared. Dentifrices were used twice per day for 30 s of lingual brushing, followed by 90 s of slurry exposure. In addition, the two specimens on the left side of the mouth were brushed for 5 s each, using a power toothbrush. All specimens were exposed to four daily erosive challenges with commercial orange juice (pH 3.6). Tooth wear was measured as enamel loss using non-contact profilometry on day 10.
At the day 10 visit, the adjusted mean (SE) enamel loss for specimens receiving slurry (erosion) treatment was 4.7 µm (0.61) [Sn-containing NaF] and 8.73 µm (1.12) [NaF control], with results demonstrating a statistically significant benefit for the Sn-containing dentifrice (46.2% benefit; p = 0.009). For specimens exposed to erosion/tooth wear conditions, enamel loss = 6.68 µm (1.29) (Sn-containing NaF) and 10.99 µm (1.29) (NaF group), with results statistically significant (p = 0.048; 39.2% better, favouring the Sn-containing dentifrice). When data were combined, enamel loss (SE) for all specimens subjected to erosion + erosion/tooth wear was 5.61 µm (0.77) (Sn-containing NaF]) and 9.9 µm (1.3) (NaF group). The difference again was statistically significant, favouring the Sn-containing group (p = 0.022; 43.4% better).
The Sn-containing dentifrice demonstrated significantly better protection than did NaF under erosive and erosive/tooth wear conditions.
将一种含实验性氟化亚锡（Sn）的氟化钠（NaF）牙膏对侵蚀和侵蚀性牙齿磨损的原位疗效与传统NaF牙膏进行比较。
这是一项随机、对照、双盲、平行组临床试验。60名一般健康的成年受试者佩戴含有四个牙釉质标本（装置每侧[左/右]各2个）的下颌装置。根据年龄和性别将受试者随机分组进行治疗。治疗包括含Sn的NaF牙膏或传统NaF牙膏。比较了侵蚀（牙膏浆处理）和侵蚀/牙齿磨损（牙膏浆加刷牙）的情况。每天使用牙膏两次，舌侧刷牙30秒，然后暴露于牙膏浆90秒。此外，用电动牙刷对口腔左侧的两个标本各刷5秒。所有标本每天接受4次用市售橙汁（pH 3.6）进行的侵蚀性刺激。在第10天使用非接触式轮廓仪测量牙齿磨损情况，以牙釉质损失量来衡量。
在第10天的随访中，接受牙膏浆（侵蚀）处理的标本的校正平均（标准误）牙釉质损失量为4.7 µm（0.61）[含Sn的NaF牙膏]和8.73 µm（1.12）[NaF对照牙膏]，结果表明含Sn牙膏具有统计学上的显著益处（益处率为46.2%；p = 0.009）。对于暴露于侵蚀/牙齿磨损情况的标本，牙釉质损失量为6.68 µm（1.29）（含Sn的NaF牙膏）和10.99 µm（1.29）（NaF组），结果具有统计学显著性（p = 0.048；含Sn牙膏更好，优势为39.2%）。当合并数据时，所有经历侵蚀 + 侵蚀/牙齿磨损的标本的牙釉质损失量（标准误）为5.61 µm（0.77）（含Sn的NaF牙膏）和9.9 µm（1.3）（NaF组）。差异再次具有统计学显著性，支持含Sn组（p = 0.022；优势为43.4%）。
在侵蚀和侵蚀/牙齿磨损条件下，含Sn牙膏比NaF牙膏表现出显著更好的保护效果。
