匹伐他汀对内皮功能的改善作用：一项荟萃分析。
Improvement of endothelial function by pitavastatin: a meta-analysis.
作者信息
Katsiki Niki, Reiner Željko, Tedeschi Reiner Eugenia, Al-Rasadi Khalid, Pirro Matteo, Mikhailidis Dimitri P, Sahebkar Amirhossein
机构信息
a Second Propedeutic Department of Internal Medicine, Medical School , Aristotle University of Thessaloniki, Hippocration Hospital , Thessaloniki , Greece.
b Department of Internal Medicine , University Hospital Centre Zagreb, School of Medicine University of Zagreb , Zagreb , Croatia.
出版信息
Expert Opin Pharmacother. 2018 Feb;19(3):279-286. doi: 10.1080/14656566.2018.1428560. Epub 2018 Jan 18.
OBJECTIVE
Dyslipidemia is commonly associated with endothelial dysfunction and increased cardiovascular risk. Pitavastatin has been shown to reduce total and low-density lipoprotein cholesterol, to increase high-density lipoprotein (HDL)-cholesterol and improve HDL function. Furthermore, several trials explored its effects on flow-mediated dilation (FMD), as an index of endothelial function. The authors evaluated the effect of pitavastatin therapy on FMD.
METHODS
The authors performed a systematic review and meta-analysis of all clinical trials exploring the impact of pitavastatin on FMD. The search included PubMed-Medline, Scopus, ISI Web of Knowledge and Google Scholar databases. Quantitative data synthesis was performed using a random-effects model, with weighted mean difference (WMD) and 95% confidence interval (CI) as summary statistics.
RESULTS
Six eligible studies comprising 7 treatment arms were selected for this meta-analysis. Overall, WMD was significant for the effect of pitavastatin on FMD (2.45%, 95% CI: 1.31, 3.60, p < 0.001) and the effect size was robust in the leave-one-out sensitivity analysis.
CONCLUSION
This meta-analysis of all available clinical trials revealed a significant increase of FMD induced by pitavastatin.
目的
血脂异常通常与内皮功能障碍及心血管风险增加相关。匹伐他汀已被证明可降低总胆固醇和低密度脂蛋白胆固醇，升高高密度脂蛋白（HDL）胆固醇并改善HDL功能。此外，多项试验探讨了其对作为内皮功能指标的血流介导的血管舒张（FMD）的影响。作者评估了匹伐他汀治疗对FMD的影响。
方法
作者对所有探讨匹伐他汀对FMD影响的临床试验进行了系统评价和荟萃分析。检索包括PubMed-Medline、Scopus、ISI Web of Knowledge和谷歌学术数据库。采用随机效应模型进行定量数据合成，以加权平均差（WMD）和95%置信区间（CI）作为汇总统计量。
结果
本荟萃分析选择了6项符合条件的研究，包括7个治疗组。总体而言，匹伐他汀对FMD的影响WMD具有显著性（2.45%，95%CI：1.31，3.60，p<0.001），且在留一法敏感性分析中效应量稳健。
结论
对所有可用临床试验的这项荟萃分析显示，匹伐他汀可显著增加FMD。
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