College of Bioscience and Biotechnology, Chubu University, Kasugai, Japan.
Theravalues Corporation, Chiyoda-ku, Japan.
Mol Nutr Food Res. 2018 Mar;62(5). doi: 10.1002/mnfr.201700731. Epub 2018 Feb 5.
The induction of brown-like adipocytes in white adipose tissue (WAT) is a potential therapeutic target for the treatment of obesity and metabolic disorders via the ability of these cells to release excess energy as heat in association with uncoupling protein 1. Some experimental trials suggest that curcumin (a yellow pigment from turmeric) has a suppressive effect on the accumulation of body fat. However, there is little evidence to show that curcumin induces the formation of brown-like adipocytes and the molecular mechanisms involved remain elusive. In addition, in most experimental trials, high doses of curcumin are administered.
Highly dispersible and bioavailable curcumin (HC, i.e., 4.5 mg native curcumin kg ) but not the same dose of native curcumin induces the formation of brown-like adipocytes in mouse inguinal WAT. Moreover, the formation of brown-like adipocytes induced by HC in inguinal WAT may be mediated by the production of local norepinephrine from accumulated alternatively activated macrophages.
These novel findings suggest that curcumin increases energy expenditure by inducing the formation of brown-like adipocytes via a unique molecular mechanism. Importantly, they show that HC has significant bioactive effects in vivo at lower doses of curcumin.
在白色脂肪组织 (WAT) 中诱导棕色样脂肪细胞是治疗肥胖和代谢紊乱的潜在治疗靶点，因为这些细胞能够通过解偶联蛋白 1 将多余的能量释放为热量。一些实验性试验表明，姜黄素（来自姜黄的黄色色素）对体脂肪的积累具有抑制作用。然而，几乎没有证据表明姜黄素能诱导棕色样脂肪细胞的形成，其涉及的分子机制仍不清楚。此外，在大多数实验性试验中，给予高剂量的姜黄素。
高分散性和生物利用度的姜黄素（HC，即 4.5 毫克天然姜黄素/kg）而不是相同剂量的天然姜黄素可诱导小鼠腹股沟 WAT 中棕色样脂肪细胞的形成。此外，HC 在腹股沟 WAT 中诱导棕色样脂肪细胞的形成可能是通过累积的交替激活的巨噬细胞产生局部去甲肾上腺素介导的。
这些新发现表明，姜黄素通过一种独特的分子机制诱导棕色样脂肪细胞的形成来增加能量消耗。重要的是，它们表明 HC 在较低剂量的姜黄素下在体内具有显著的生物活性作用。
