Division of Nutrology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil.
Departament of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil.
Eur J Nutr. 2020 Feb;59(1):93-102. doi: 10.1007/s00394-018-1887-7. Epub 2019 Jan 2.
This experimental study investigated the effects of curcuma supplementation on weight gain, Body Adiposity Index, glucose and lipid profile, and liver and pancreas histology in C57BL/6 mice fed with a high-fat diet.
40 animals were separated into four groups: standard diet (SD), standard diet plus curcuma (SD + C), high-fat diet (HFD), and high-fat diet plus curcuma (HFD + C). Curcuma dose was 8 mg/animal/day. Histological and biochemical analyses were performed at the end of the experimental period.
Curcuma prevented weight gain, despite a higher food intake, and increased brown adipose tissue weight only in mice receiving standard diet. However, these changes were not observed in HFD + C group. The groups that received curcuma (SD + C and HFD + C) showed a pancreas with diffuse macro- and microgoticular steatosis.
Curcuma supplementation did not prevent weight gain or improved glucose and lipid profile in mice receiving high-fat diet. Furthermore, there was evidence of possible curcuma toxicity in the pancreas of C57BL/6 mice. The implications of these findings on humans still need to be investigated.
本实验研究了姜黄素补充剂对高脂肪饮食喂养的 C57BL/6 小鼠体重增加、体脂指数、血糖和血脂谱以及肝脏和胰腺组织学的影响。
将 40 只动物分为四组：标准饮食（SD）、标准饮食加姜黄素（SD+C）、高脂肪饮食（HFD）和高脂肪饮食加姜黄素（HFD+C）。姜黄素剂量为 8mg/动物/天。在实验期末进行组织学和生化分析。
尽管姜黄素组的食物摄入量较高，但姜黄素预防了体重增加，并仅在接受标准饮食的小鼠中增加了棕色脂肪组织的重量。然而，在 HFD+C 组中没有观察到这些变化。接受姜黄素的组（SD+C 和 HFD+C）的胰腺显示弥漫性大、小脂肪滴性脂肪变性。
姜黄素补充剂不能预防高脂肪饮食喂养的小鼠体重增加或改善血糖和血脂谱。此外，C57BL/6 小鼠胰腺中存在姜黄素可能毒性的证据。这些发现对人类的影响仍需进一步研究。
