Department of Experimental Immunology, Medical University of Lodz, Lodz, Poland.
Obes Rev. 2018 May;19(5):686-697. doi: 10.1111/obr.12670. Epub 2018 Jan 15.
Obesity is reckoned as one of the civilization diseases, posing a considerable global health issue. Evidence points towards a contribution of multitude immune cell populations in obesity pathomechanism and the development of chronic low-grade inflammation in the expanded adipose tissue. Notably, adipose tissue is a reservoir of mast cells which number in individuals with obesity particularly increased. Some of them tend to degranulation what generate secretion of strong pro-inflammatory and regulatory mediators, as well as cytokines/chemokines. Several lines of evidence suggest that mast cells are strictly associated with pro-inflammatory status in adipose tissue by their indirect impact on immune cell attraction and activation. Furthermore, mast cells affect adipose tissue remodelling and fibrosis by adipocyte differentiation, fibroblast proliferation and enhancing extracellular matrix proteins expression. This review will summarize current knowledge on mast cell features and their role in the development of chronic low-grade inflammation within adipose tissue.
肥胖被认为是一种文明病，是一个相当严重的全球健康问题。有证据表明，在肥胖的发病机制和扩张的脂肪组织中慢性低度炎症的发展过程中，多种免疫细胞群体发挥了作用。值得注意的是，脂肪组织是肥大细胞的储存库，肥胖个体的肥大细胞数量特别多。其中一些肥大细胞趋向脱颗粒，从而产生强烈的促炎和调节介质以及细胞因子/趋化因子的分泌。有几条证据表明，肥大细胞通过间接影响免疫细胞的趋化和激活，与脂肪组织中的促炎状态密切相关。此外，肥大细胞通过脂肪细胞分化、成纤维细胞增殖和增强细胞外基质蛋白的表达来影响脂肪组织的重塑和纤维化。这篇综述将总结目前关于肥大细胞特征及其在脂肪组织内慢性低度炎症发展中的作用的知识。
