Department of Cardiac, Thoracic and Vascular Sciences, Public Health Unit, University of Padua, Padua, Italy.
Department of Public Health and Community Medicine, Hygiene and Environmental, Occupational and Preventive Medicine Division, University of Verona, Verona, Italy.
BMC Infect Dis. 2018 Jan 15;18(1):41. doi: 10.1186/s12879-018-2954-7.
Genital warts are one of the most common forms of sexually-transmitted disease, but their epidemiology has yet to be thoroughly elucidated. The present study was designed to shed light on the prevalence of clinically-confirmed, self-reported genital warts (GWs) in a representative sample of the university population.
In 2015, a cross-sectional survey was conducted on 11,096 individuals approached at the Students Information Bureau where they came to enroll for a university degree course. Participants completed an anonymous, self-administered questionnaire providing information on their sociodemographic characteristics, sexual behavior, and any history of clinically-diagnosed genital warts. Multivariate logistic regression was then used to identify any factors associated with the disease.
Our analysis was conducted on 9259 questionnaires (83.4%). Participants were a mean 21.8 ± 4.8 years of age, and 59.6% were female. Overall, 124 individuals (1.3%, 95%CI: 1.0-1.6) reported having been diagnosed with genital warts: 48 men (1.3%, 95%CI: 0.9-1.6), and 76 women (1.4% 95%CI: 1.1-1.7). Overall, 22.5% of the sample were vaccinated (1.3% of the males and 36.8% of the females). The group of respondents aged 30 years or more had the highest incidence of genital warts (males: 5.6%, 95%CI: 2.5-8.6; females: 6.9%, 95%CI: 3.4-10.4). The independent risk factors associated with a history of disease were (for both genders) a history of other sexually-transmitted diseases, and ≥2 sex partners in the previous 24 months. A protective role emerged for routine condom use. Additional risk factors associated with genital warts in males concerned men who have sex with men, bisexuality vis-à-vis heterosexuality, and smoking.
The findings emerging from our study help to further clarify the epidemiology of genital warts in young people, and may be useful to public health decision-makers. This study showed that genital warts occur in men as well as women, and suggests that both genders should be monitored for this disease to ascertain the effects of the free HPV vaccination offered to all girls in the Veneto in their 12th year of life since 2008, and to all boys of the same age since 2015.
生殖器疣是最常见的性传播疾病之一，但它们的流行病学尚未得到充分阐明。本研究旨在阐明在大学生人群的代表性样本中，临床确诊的自我报告生殖器疣（GWs）的流行情况。
2015 年，对在学生信息局前来注册大学学位课程的 11096 人进行了横断面调查。参与者完成了匿名的自我管理问卷，提供了他们的社会人口统计学特征、性行为以及任何临床诊断为生殖器疣的病史信息。然后使用多变量逻辑回归来确定与该疾病相关的任何因素。
我们对 9259 份问卷（83.4%）进行了分析。参与者的平均年龄为 21.8±4.8 岁，其中 59.6%为女性。总体而言，124 人（1.3%，95%CI：1.0-1.6）报告被诊断患有生殖器疣：48 名男性（1.3%，95%CI：0.9-1.6）和 76 名女性（1.4%，95%CI：1.1-1.7）。总体而言，22.5%的样本接受了疫苗接种（男性 1.3%，女性 36.8%）。年龄在 30 岁或以上的受访者生殖器疣发病率最高（男性：5.6%，95%CI：2.5-8.6；女性：6.9%，95%CI：3.4-10.4）。与疾病史相关的独立危险因素是（男女均有）其他性传播疾病史和过去 24 个月内有≥2 个性伴侣。常规使用避孕套具有保护作用。与男性生殖器疣相关的其他危险因素包括男男性行为、双性恋与异性恋以及吸烟。
本研究结果有助于进一步阐明年轻人中生殖器疣的流行病学，并可为公共卫生决策者提供参考。本研究表明，生殖器疣不仅发生在男性，也发生在女性中，这表明应该监测两性的这种疾病，以确定自 2008 年以来为所有 12 岁的维内托女孩和自 2015 年以来所有 12 岁的男孩免费提供 HPV 疫苗接种的效果。
