口服避孕药与尖锐湿疣有关联吗？
Is oral contraceptive associated with genital warts?
作者信息
Ross J D
机构信息
Department of Genitourinary Medicine, Edinburgh Royal Infirmary, UK.
出版信息
Genitourin Med. 1996 Oct;72(5):330-3. doi: 10.1136/sti.72.5.330.
OBJECTIVE
To measure the association between oral contraceptive use and the prevalence of genital warts in women.
METHODS
Cross sectional case control study comparing oral contraceptive use in women with and without genital warts attending a city centre genitourinary medicine clinic controlling for recent sexual activity, the presence of other sexually transmitted infections, socio-economic class and history of pregnancy using a multivariate logistic regression model.
RESULTS
After controlling for potential confounding variables women with genital warts were significantly more likely to be current users of the oral contraceptive pill (OR 1.7, 95% CI 1.3-2.2).
CONCLUSION
The study suggests that women taking the oral contraceptive may be at increased risk of presenting with genital warts. Previously published papers provide some support for this hypothesis and potential biological mechanisms are discussed.
目的
测量女性口服避孕药的使用与尖锐湿疣患病率之间的关联。
方法
进行横断面病例对照研究，比较在市中心泌尿生殖医学诊所就诊的有和没有尖锐湿疣的女性口服避孕药的使用情况，使用多变量逻辑回归模型控制近期性行为、其他性传播感染的存在、社会经济阶层和怀孕史。
结果
在控制潜在混杂变量后，患有尖锐湿疣的女性更有可能是口服避孕药的当前使用者（比值比1.7，95%置信区间1.3 - 2.2）。
结论
该研究表明，服用口服避孕药的女性患尖锐湿疣的风险可能增加。先前发表的论文为这一假设提供了一些支持，并讨论了潜在的生物学机制。
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