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Serologically diagnosed infection with human papillomavirus type 16 and risk for subsequent development of cervical carcinoma: nested case-control study.血清学诊断的16型人乳头瘤病毒感染与后续宫颈癌发生风险：巢式病例对照研究
BMJ. 1996 Mar 2;312(7030):537-9. doi: 10.1136/bmj.312.7030.537.
2
Natural killer cell activity in endometriosis: correlation between serum estradiol levels and cytotoxicity.子宫内膜异位症中的自然杀伤细胞活性：血清雌二醇水平与细胞毒性之间的相关性。
Obstet Gynecol. 1993 May;81(5 ( Pt 1)):665-8.
3
Human papillomavirus and invasive cervical cancer in Brazil.巴西的人乳头瘤病毒与浸润性宫颈癌
Br J Cancer. 1994 Jan;69(1):114-9. doi: 10.1038/bjc.1994.18.
4
Determinants of genital human papillomavirus infection among cytologically normal women attending the University of New Mexico student health center.在新墨西哥大学学生健康中心就诊的细胞学正常女性中，生殖道人乳头瘤病毒感染的决定因素。
Sex Transm Dis. 1993 Sep-Oct;20(5):286-9. doi: 10.1097/00007435-199309000-00009.
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Determinants of genital human papillomavirus infection in low-income women in Washington, D.C.华盛顿特区低收入女性生殖器人乳头瘤病毒感染的决定因素
Sex Transm Dis. 1993 Sep-Oct;20(5):279-85. doi: 10.1097/00007435-199309000-00008.
6
Determinants of genital human papillomavirus infection in low-risk women in Portland, Oregon.俄勒冈州波特兰市低风险女性生殖器人乳头瘤病毒感染的决定因素
Sex Transm Dis. 1993 Sep-Oct;20(5):274-8. doi: 10.1097/00007435-199309000-00007.
7
Health gains from screening for infection of the lower genital tract in women attending for termination of pregnancy.对前来终止妊娠的女性进行下生殖道感染筛查所带来的健康益处。
Lancet. 1993 Jul 24;342(8865):206-10. doi: 10.1016/0140-6736(93)92299-9.
8
Oral contraceptive use and adenocarcinoma of cervix.口服避孕药的使用与宫颈癌
Lancet. 1994 Nov 19;344(8934):1390-4. doi: 10.1016/s0140-6736(94)90567-3.
9
Risk factors for cervical intraepithelial neoplasia: differences between low- and high-grade lesions.宫颈上皮内瘤变的危险因素：低级别和高级别病变之间的差异
Am J Epidemiol. 1994 Oct 15;140(8):700-10. doi: 10.1093/oxfordjournals.aje.a117318.
10
Characteristics of women with dysplasia or carcinoma in situ of the cervix uteri.子宫颈发育异常或原位癌女性的特征。
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口服避孕药与尖锐湿疣有关联吗？

Is oral contraceptive associated with genital warts?

作者信息

Ross J D

机构信息

Department of Genitourinary Medicine, Edinburgh Royal Infirmary, UK.

出版信息

Genitourin Med. 1996 Oct;72(5):330-3. doi: 10.1136/sti.72.5.330.

DOI:10.1136/sti.72.5.330
PMID:8976847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1195698/
Abstract

OBJECTIVE

To measure the association between oral contraceptive use and the prevalence of genital warts in women.

METHODS

Cross sectional case control study comparing oral contraceptive use in women with and without genital warts attending a city centre genitourinary medicine clinic controlling for recent sexual activity, the presence of other sexually transmitted infections, socio-economic class and history of pregnancy using a multivariate logistic regression model.

RESULTS

After controlling for potential confounding variables women with genital warts were significantly more likely to be current users of the oral contraceptive pill (OR 1.7, 95% CI 1.3-2.2).

CONCLUSION

The study suggests that women taking the oral contraceptive may be at increased risk of presenting with genital warts. Previously published papers provide some support for this hypothesis and potential biological mechanisms are discussed.

摘要

目的

测量女性口服避孕药的使用与尖锐湿疣患病率之间的关联。

方法

进行横断面病例对照研究，比较在市中心泌尿生殖医学诊所就诊的有和没有尖锐湿疣的女性口服避孕药的使用情况，使用多变量逻辑回归模型控制近期性行为、其他性传播感染的存在、社会经济阶层和怀孕史。

结果

在控制潜在混杂变量后，患有尖锐湿疣的女性更有可能是口服避孕药的当前使用者（比值比1.7，95%置信区间1.3 - 2.2）。

结论

该研究表明，服用口服避孕药的女性患尖锐湿疣的风险可能增加。先前发表的论文为这一假设提供了一些支持，并讨论了潜在的生物学机制。