沙特阿拉伯西南部某省医院污水和城市污水中碳青霉烯耐药基因（KPC）、万古霉素耐药基因（van A/B）及甲氧西林耐药基因（mecA）的流行情况
Prevalence of a carbapenem-resistance gene (KPC), vancomycin-resistance genes (van A/B) and a methicillin-resistance gene (mecA) in hospital and municipal sewage in a southwestern province of Saudi Arabia.
作者信息
Basode Vinod Kumar, Abdulhaq Ahmed, Alamoudi Mohammed Uthman A, Tohari Hassan Mohammad, Quhal Waleed Ali, Madkhali Aymen Mohammed, Hobani Yahya Hasan, Hershan Almonther Abdullah
机构信息
Unit of Medical Microbiology, Department of Medical Lab Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Deanship of Scientific Affairs and Research, Jazan University, Jazan, Saudi Arabia.
出版信息
BMC Res Notes. 2018 Jan 15;11(1):30. doi: 10.1186/s13104-018-3167-2.
OBJECTIVE
According to the World Health Organization, the increasing antibiotic resistance of pathogens is one of the most important threats to human health. Prevalence of a carbapenem-resistance gene (KPC), vancomycin-resistance genes (van A/B) and a methicillin-resistance gene (mecA) in hospital and municipal sewages will be potential threat to public health.
RESULTS
Vancomycin-resistance genes were detected in the sewage of community tank-II, sewage tank of the tertiary and general hospital. Carbapenem-resistance gene was detected in sewage of community tank-II and sewage from tertiary hospital. Methicillin-resistance gene was detected in sewage of community tank-II, sewage from a fish market sewage tank and sewage from an animal slaughter house sewage tank. The detection of a KPC, van A/B and a mecA in sewages will help further the process to take the appropriate measures to prevent the spread of such bacteria in the environment.
目的
根据世界卫生组织的说法，病原体对抗生素的耐药性不断增加是对人类健康最重要的威胁之一。医院污水和城市污水中碳青霉烯耐药基因（KPC）、万古霉素耐药基因（van A/B）和甲氧西林耐药基因（mecA）的存在将对公众健康构成潜在威胁。
结果
在社区二号化粪池污水、三级医院和综合医院的污水池中检测到了万古霉素耐药基因。在社区二号化粪池污水和三级医院污水中检测到了碳青霉烯耐药基因。在社区二号化粪池污水、鱼市污水池污水和动物屠宰场污水池污水中检测到了甲氧西林耐药基因。在污水中检测到KPC、van A/B和mecA将有助于进一步采取适当措施，防止此类细菌在环境中传播。
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