Radiotherapy Unit, 1st Department of Radiology, Medical School, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Radiotherapy Unit, 2nd Department of Radiology, Medical School, ATTIKON University Hospital, National and Kapodistrian University of Athens, Rimini 1, 12462, Chaidari, Greece.
Clin Transl Oncol. 2018 Aug;20(8):989-1003. doi: 10.1007/s12094-018-1831-6. Epub 2018 Jan 15.
GBM is one of the most common and aggressive brain tumors. Surgery and adjuvant chemoradiation have succeeded in providing a survival benefit. Although most patients will eventually experience local recurrence, the means to fight recurrence are limited and prognosis remains poor. In a disease where local control remains the major challenge, few trials have addressed the efficacy of local treatments, either surgery or radiation therapy. The present article reviews recent advances in the biology, imaging and biomarker science of GBM as well as the current treatment status of GBM, providing new perspectives to the problem of local recurrence.
GBM 是最常见和侵袭性的脑肿瘤之一。手术和辅助放化疗已成功提供生存获益。尽管大多数患者最终会经历局部复发，但治疗复发的手段有限，预后仍然较差。在局部控制仍然是主要挑战的疾病中，很少有试验研究局部治疗（手术或放疗）的疗效。本文综述了 GBM 的生物学、影像学和生物标志物科学的最新进展以及 GBM 的当前治疗状况，为局部复发问题提供了新的视角。
