Coindre J M, Mage P, Bui B N, Goussot J F, De Mascarel I, De Mascarel A, Trojani M
Presse Med. 1985 Oct 19;14(35):1823-7.
A clinical, biochemical and histomorphometric study of non-decalcified bone with measurement of calcification rate was carried out in 10 patients with sclerotic bone metastases from prostatic carcinoma. The patients were under oestrogen therapy, and a change of treatment was being considered. The histomorphometric study showed that 3 patients had osteomalacia. These patients differed from the others in that the pain they experienced in bones was stronger, more diffuse and more often permanent. All three had fracture of the femoral neck. They had hypocalcaemia, hypophosphataemia, hypocalciuria and increased serum alkaline phosphatase, but only phosphataemia was significantly lower than in non-osteomalacia patients. Osteomalacia was cured by vitamin D and calcium in one patient. Osteomalacia can only be reliably diagnosed in these patients by histomorphometry. This examination may be proposed to patients with sclerotic bone metastasis of prostatic origin, under hormonal therapy, presenting with diffuse skeletal pain or bone fragility without osteolysis, and with hypocalcaemia or hypophosphataemia.
对10例前列腺癌骨硬化转移患者的未脱钙骨进行了临床、生化和组织形态计量学研究，并测量了钙化率。这些患者正在接受雌激素治疗，且正在考虑改变治疗方案。组织形态计量学研究显示，3例患者患有骨软化症。这些患者与其他患者的不同之处在于，他们骨骼疼痛更强、更弥漫且更常持续。三人都有股骨颈骨折。他们有低钙血症、低磷血症、低钙尿症和血清碱性磷酸酶升高，但只有磷血症显著低于非骨软化症患者。一名患者的骨软化症通过维生素D和钙治愈。在这些患者中，骨软化症只能通过组织形态计量学可靠诊断。对于前列腺来源的骨硬化转移、接受激素治疗、出现弥漫性骨骼疼痛或无骨质溶解的骨脆性、伴有低钙血症或低磷血症的患者，可建议进行此项检查。
