Charhon S A, Chapuy M C, Delvin E E, Valentin-Opran A, Edouard C M, Meunier P J
Cancer. 1983 Mar 1;51(5):918-24. doi: 10.1002/1097-0142(19830301)51:5<918::aid-cncr2820510526>3.0.co;2-j.
Transiliac undecalcified bone biopsy specimens were taken after tetracycline double labeling from 14 patients with radiologic evidence of osteosclerotic metastases from prostatic carcinoma. The histomorphometric analysis showed an increased trabecular bone volume in all patients, and in seven morphologic and dynamic evidence of osteomalacia (Group 1). The seven other patients demonstrated an extension of apposition surfaces without evidence of osteomalacia (Group 2). Group 1 was different from Group 2 in terms of a greater increase in serum alkaline phosphatase and a lower urinary calcium. In four Group 1 patients, a second bone sample taken after two to six months of treatment with vitamin D and calcium provided evidence of improving osteomalacia. The high incidence of osteomalacia in osteosclerotic metastases of prostatic origin appears to be the result of the increase in bone formation induced by prostatic cells, and the unability to satisfy the high calcium demand for new bone.
在四环素双重标记后，从14例有前列腺癌骨硬化转移放射学证据的患者身上获取经髂骨未脱钙骨活检标本。组织形态计量学分析显示，所有患者的小梁骨体积均增加，其中7例有骨软化的形态学和动力学证据（第1组）。其他7例患者显示骨表面沉积增加，但无骨软化证据（第2组）。第1组与第2组的不同之处在于血清碱性磷酸酶升高幅度更大，尿钙水平更低。在4例第1组患者中，在接受维生素D和钙治疗2至6个月后采集的第二份骨样本显示骨软化有所改善。前列腺来源的骨硬化转移中骨软化的高发生率似乎是前列腺细胞诱导的骨形成增加以及无法满足新骨形成对高钙需求的结果。
