在术中会诊时，细胞凋亡的存在可将原发性中枢神经系统淋巴瘤与胶质母细胞瘤区分开来。
Presence of apoptosis distinguishes primary central nervous system lymphoma from glioblastoma during intraoperative consultation.
作者信息
Cha Yoon Jin, Choi Junjeong, Kim Se Hoon
出版信息
Clin Neuropathol. 2018 May/Jun;37(3):105-111. doi: 10.5414/NP301075.
AIM
To evaluate the overlapping and distinguishing cytologic features of primary central nervous system lymphoma (PCNSL), diffuse large B-cell lymphoma, and glioblastoma (GM) in frozen sections and squash smear slides.
MATERIALS AND METHODS
Intraoperative frozen sections and squash smear slides from PCNSL (N = 63) and GM (N = 122) patients diagnosed from 2005 to 2015 were retrieved from pathology records. Overlapping and distinguishing histologic features were examined and statistically analyzed.
RESULTS
Necrosis and moderate nuclear size variation were common features of PCNSL and GM. PCNSL characteristically showed apoptosis, lack of a fibrillary background, monotonous nuclei, scant cytoplasm, lack of microvascular proliferation, and presence of perivascular cuffing. Multivariate analysis revealed that presence of apoptosis was the most powerful predictive parameter for the diagnosis of PCNSL.
CONCLUSION: The presence of apoptosis was effective for the intraoperative diagnosis of PCNSL compared to GM. .
目的
评估原发性中枢神经系统淋巴瘤（PCNSL）、弥漫性大B细胞淋巴瘤和胶质母细胞瘤（GM）在冰冻切片和压片涂片玻片上的重叠及鉴别细胞学特征。
材料与方法
从病理记录中检索出2005年至2015年诊断的PCNSL患者（N = 63）和GM患者（N = 122）的术中冰冻切片和压片涂片玻片。对重叠和鉴别的组织学特征进行检查并进行统计学分析。
结果
坏死和中等程度的核大小变异是PCNSL和GM的常见特征。PCNSL的特征性表现为凋亡、缺乏纤维背景、核形态单一、胞质稀少、无微血管增生以及血管周围套袖样改变。多因素分析显示，凋亡的存在是诊断PCNSL最有力的预测参数。
结论
与GM相比，凋亡的存在对PCNSL的术中诊断有效。
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