EHMT2是乳腺癌中的一种转移调节因子。
EHMT2 is a metastasis regulator in breast cancer.
作者信息
Kim Kwangho, Son Mi-Young, Jung Cho-Rok, Kim Dae-Soo, Cho Hyun-Soo
机构信息
Korea Research Institute of Bioscience and Biotechnology, Daejeon, 305-333, Republic of Korea.
Korea Research Institute of Bioscience and Biotechnology, Daejeon, 305-333, Republic of Korea; Department of Functional Genomics, Korea University of Science and Technology, Daejeon, 305-333, Republic of Korea.
出版信息
Biochem Biophys Res Commun. 2018 Feb 5;496(2):758-762. doi: 10.1016/j.bbrc.2018.01.074. Epub 2018 Jan 11.
Various modes of epigenetic regulation of breast cancer proliferation and metastasis have been investigated, but epigenetic mechanisms involved in breast cancer metastasis remain elusive. Thus, in this study, EHMT2 (a histone methyltransferase) was determined to be significantly overexpressed in breast cancer tissues and in Oncomine data. In addition, knockdown of EHMT2 reduced cell migration/invasion and regulated the expression of EMT-related markers (E-cadherin, Claudin 1, and Vimentin). Furthermore, treatment with BIX-01294, a specific inhibitor of EHMT2, affected migration/invasion in MDA-MB-231 cells. Therefore, our findings demonstrate functions of EHMT2 in breast cancer metastasis and suggest that targeting EHMT2 may be an effective therapeutic strategy for preventing breast cancer metastasis.
人们已经研究了乳腺癌增殖和转移的各种表观遗传调控模式，但参与乳腺癌转移的表观遗传机制仍不清楚。因此，在本研究中，发现EHMT2（一种组蛋白甲基转移酶）在乳腺癌组织和Oncomine数据中显著过表达。此外，敲低EHMT2可减少细胞迁移/侵袭，并调节上皮-间质转化（EMT）相关标志物（E-钙黏蛋白、Claudin 1和波形蛋白）的表达。此外，用EHMT2的特异性抑制剂BIX-01294处理会影响MDA-MB-231细胞的迁移/侵袭。因此，我们的研究结果证明了EHMT2在乳腺癌转移中的作用，并表明靶向EHMT2可能是预防乳腺癌转移的有效治疗策略。
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