Ravaioli Francesco, Bacalini Maria G, Franceschi Claudio, Garagnani Paolo
Department of Specialty, Diagnostic and Experimental Medicine (DIMES), Via San Giacomo 12, 40126 Bologna, Italy.
CIG, Interdepartmental Center 'L. Galvani', Alma Mater Studiorum, Via G. Petroni 26, 40126 Bologna, Italy.
Genes (Basel). 2018 Jan 16;9(1):39. doi: 10.3390/genes9010039.
Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of studies have been describing the generation of induced pluripotent stem cells (iPSCs) from old or centenarian biologic material. Nonetheless, Reprogramming techniques determine a profound remodelling on cell epigenetic architecture whose extent is still largely debated. Given that cell epigenetic profile changes with age, the study of cell-fate manipulation approaches on cells deriving from old donors or centenarians may provide new insights not only on regenerative features and physiology of these cells, but also on reprogramming-associated and age-related epigenetic derangement.
衰老 是一种复杂的多层次现象。对人类衰老的研究基于使用来自难以获取的组织和高度特定队列的生物材料。细胞重编程技术的引入为医学实践和基础研究带来了有前景的特性。最近，越来越多的研究描述了从老年或百岁老人生物材料中诱导多能干细胞（iPSC）的产生。尽管如此，重编程技术会对细胞表观遗传结构产生深刻的重塑，其程度仍在很大程度上存在争议。鉴于细胞表观遗传特征随年龄变化，对来自老年供体或百岁老人的细胞进行细胞命运操控方法的研究不仅可能为这些细胞的再生特性和生理学提供新见解，还可能为与重编程相关和与年龄相关的表观遗传紊乱提供新见解。
