一种来自日本金粟兰的新型环烯醚萜类倍半萜内酯。
A new lindenane-type sesquiterpenoid lactone from Chloranthus japonicus.
作者信息
Jiang Cheng-Shi, Guo Yan-Qiong, Yin Sheng, Zhang Hua, Tang Gui-Hua
机构信息
a School of Biological Science and Technology , University of Jinan , Jinan 250022 , China.
b School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , China.
出版信息
J Asian Nat Prod Res. 2019 Apr;21(4):377-383. doi: 10.1080/10286020.2018.1424138. Epub 2018 Jan 17.
Chromatographic fractionation of the EtOH extracts of the Traditional Chinese Medicine (TCM) Chloranthus japonicus, has led to the isolation of a new lindenane-type sesquiterpenoid lactone derivative (1). Rosmarylchloranthalactone E (1), which consists of lindenane sesquiterpenoid lactone and rosmarinic acid moieties linked via an ester bridge, was structurally elucidated by 1D and 2D NMR and HRMS data. Compound 1 was a potent phosphodiesterase-4 (PDE4) inhibitor with an IC value of 0.96 ± 0.04 μM.
对中药宽叶金粟兰乙醇提取物进行色谱分离，得到了一种新的银叶烷型倍半萜内酯衍生物（1）。迷迭香金粟兰内酯E（1）由银叶烷倍半萜内酯和迷迭香酸部分通过酯桥相连组成，通过一维和二维核磁共振及高分辨质谱数据对其结构进行了阐明。化合物1是一种有效的磷酸二酯酶-4（PDE4）抑制剂，IC值为0.96±0.04μM。
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