抗炎里兰烷倍半萜二聚体来自金粟兰科金粟兰属三序金粟兰的根。
Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus.
机构信息
Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
School of Food Science and Pharmaceutical Engineering, Testing & Analysis Center, Nanjing Normal University, Xuelin Road No. 2, Nanjing, 210023, People's Republic of China.
出版信息
J Nat Med. 2024 Sep;78(4):995-1002. doi: 10.1007/s11418-024-01817-y. Epub 2024 May 12.
Two new lindenane-type sesquiterpenoid dimers, chlotrichenes C and D (1 and 2) together with five known lindenane-type sesquiterpenoid dimers (3-7) were isolated from the roots of Chloranthus holostegius var. trichoneurus, a famous natural medicine named as "Sikuaiwa" for subduing swellings and relieving pain. The structures including absolute configuration were elucidated by their 1D and 2D NMR, HRESIMS, and ECD data. Compounds 1 and 2 were classical [4 + 2] lindenane-type sesquiterpenoid dimers that differed from known analogs in oxidation profile, side chain profile, and double bond position. The new isolates and compound 3 exhibited significant inhibitory activity on IL-1β production (IC: 1-15 μM) in LPS-induced THP-1 cells and other compounds exhibited inhibitory activity on NO production in LPS-induced RAW 264.7 cells (IC: 24-33 μM).
从著名的天然药材“四块瓦”（即金粟兰 Chloranthus holostegius var. trichoneurus 的根部分离得到两种新的里兰烷型倍半萜二聚体，即氯替芬 C 和 D（1 和 2），以及五种已知的里兰烷型倍半萜二聚体（3-7）。通过它们的 1D 和 2D NMR、HRESIMS 和 ECD 数据，阐明了包括绝对构型在内的结构。化合物 1 和 2 是经典的[4+2]里兰烷型倍半萜二聚体，它们在氧化谱、侧链谱和双键位置上与已知类似物不同。新的分离物和化合物 3 对 LPS 诱导的 THP-1 细胞中 IL-1β 产生具有显著的抑制活性（IC：1-15 μM），而其他化合物对 LPS 诱导的 RAW 264.7 细胞中 NO 产生具有抑制活性（IC：24-33 μM）。
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