氯雷他定 A，一种来自金粟兰属的倍半萜二聚体。
Chloraserrtone A, a Sesquiterpenoid Dimer from Chloranthus serratus.
机构信息
School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , Guangdong 510006 , People's Republic of China.
Guangdong Technology Research Center for Advanced Chinese Medicine , Guangzhou , Guangdong 510006 , People's Republic of China.
出版信息
J Nat Prod. 2019 Feb 22;82(2):407-411. doi: 10.1021/acs.jnatprod.8b00418. Epub 2019 Feb 6.
Chloraserrtone A (1), a new sesquiterpenoid dimer with two lindenane-type sesquiterpenoid monomers bridged by two six-membered rings, was obtained from Chloranthus serratus. A combination of UV, IR, NMR, HRESIMS, and X-ray diffraction data were used to elucidate the structure of 1. Compound 1 represents the first lindenane-type sesquiterpenoid dimer with extremely unique C-15-C-15', C-4-C-6', and C-6-C-11' linkages to form two six-membered rings between the monomeric units. A plausible biosynthesis toward chloraserrtone A is proposed. This new compound (1), together with the known lindenane dimers (2-11), were assessed for their inhibitory effects on lipopolysaccharide-induced NO production in RAW264.7 cells. Compound 6 showed activity with an IC value of 3.7 μM.
氯雷他酮 A（1）是一种新的倍半萜二聚体，由两个六元环桥接的两个 Lindenane 型倍半萜单体组成，从金粟兰属植物 Chloranthus serratus 中获得。采用 UV、IR、NMR、HRESIMS 和 X 射线衍射数据的组合来阐明 1 的结构。化合物 1 代表第一个 Lindenane 型倍半萜二聚体，具有极其独特的 C-15-C-15'、C-4-C-6'和 C-6-C-11'键合，在单体单元之间形成两个六元环。提出了对氯雷他酮 A 的可能生物合成途径。该新化合物（1）与已知的 Lindenane 二聚体（2-11）一起评估了它们对 RAW264.7 细胞中脂多糖诱导的 NO 产生的抑制作用。化合物 6 表现出活性，IC 值为 3.7 μM。
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