Rewarding effects of physical activity predict sensitivity to the acute subjective effects of d-amphetamine in healthy volunteers.

While individual differences in reward sensitivity are believed to generalize across drugs and alternative rewards, this notion has received little empirical attention in human research. Here, we tested whether individual differences in the subjective rewarding effects of physical activity were associated with the subjective response to d-amphetamine administration. Healthy volunteers ( n=95; age 18-35 years) completed questionnaires measuring the self-reported pleasurable effects of physical activity and other covariates, and this was followed by two double-blind counterbalanced sessions during which they received either 20 mg oral d-amphetamine or placebo. Subjective drug effects measures were collected before and repeatedly after drug administration. Subjective d-amphetamine-related effects were then reduced via principal components analysis into latent factors of "positive mood," "arousal," and "drug high." Multiple regression models controlling for placebo-related scores, session order, demographics, body mass index, level of physical activity, and use of other drugs showed that degree of self-reported physical activity reward was positively associated with d-amphetamine-induced positive mood and arousal ( βs≥0.25, ps≤0.04), but was not associated with d-amphetamine-induced changes in drug high ( β=0.13, p=0.24). These results provide novel evidence suggesting that individual differences in reward sensitivity cross over between d-amphetamine reward and physical activity reward in humans.