a Department of Pathology , The University of Texas, M D Anderson Cancer Center , Houston , TX , USA.
Expert Rev Respir Med. 2018 Mar;12(3):249-255. doi: 10.1080/17476348.2018.1428563. Epub 2018 Jan 17.
Primary mucoepidermoid carcinomas (MEC) of the lung are rare and represent a diagnostic challenge. MEC in the lung is under the umbrella of primary salivary gland type tumors of the lung. Areas covered: In general, salivary gland type tumors are represented by malignant neoplasms that may range from low to intermediate to high-grade type of malignancy sharing similar histopathological features as those in salivary glands. The focus in this review will be on one tumor in particular - mucoepidermoid carcinoma. Clinical, radiological, histopathological, and molecular diagnostic features will be highlighted in order to provide an insight on this unusual tumor in the lung. In addition, the treatment of these tumors will be discussed. Expert commentary: It is important to stress that in the majority of cases, the proper use of histopathological assessment is the most important step in arriving at an accurate diagnosis. It is also important to recognized that there are other unusual primary tumoral conditions of the lung, which may pose a significant challenge in the differential diagnosis. The importance of proper recognition of mucoepidermoid carcinoma and its grading will be highlighted in order to assess clinical outcome.
原发性肺黏液表皮样癌（MEC）较为罕见，诊断具有挑战性。肺 MEC 属于肺原发性涎腺型肿瘤。涵盖领域：一般而言，涎腺型肿瘤表现为恶性肿瘤，恶性程度可低、中或高，具有与涎腺相似的组织病理学特征。本综述的重点将是一种特定的肿瘤——黏液表皮样癌。将突出介绍其临床、放射学、组织病理学和分子诊断特征，以便深入了解肺部这种不常见的肿瘤。此外，还将讨论这些肿瘤的治疗方法。专家评论：必须强调的是，在大多数情况下，正确使用组织病理学评估是得出准确诊断的最重要步骤。还需要认识到，肺内还有其他罕见的原发性肿瘤疾病，这可能在鉴别诊断中构成重大挑战。突出强调正确识别黏液表皮样癌及其分级的重要性，以便评估临床结局。
