Huang Shengyun, Zhang Yarong, Wumener Xieraili, Lei Yuanyuan, Liang Ying
Department of Nuclear Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Front Oncol. 2024 Sep 26;14:1447843. doi: 10.3389/fonc.2024.1447843. eCollection 2024.
A 70-year-old woman underwent distal gastrectomy due to gastric adenocarcinoma in 2015. After 6 years, the follow-up CT revealed a suspicious mass in the right hilar of the lung mimicking mediastinal lymph nodes. Further dynamic PET/CT images showed a mass located in the right intermediate bronchus with increased FDG uptake and relatively high Ki value, which may imply the possibility of malignancy. However, the symmetrical mediastinal lymph nodes had intense FDG uptake but relatively low Ki value, suggesting benign lesions. The initial pathological result of the bronchoscopy biopsy was considered suspicious for metastatic gastric adenocarcinoma. However, it was then found consistent with middle-grade mucoepidermoid carcinoma, considered a second primary cancer without metastatic lymph nodes as confirmed by a surgical procedure (lower bilobectomy + hilar and mediastinal lymphadenectomy). F-FDG PET/CT has an important value in the follow-up of indeterminate findings for patients with a tumor history. Moreover, dynamic quantification parameters such as Ki may be additionally helpful in identifying malignancies in some equivocal situations.
一名70岁女性于2015年因胃腺癌接受了远端胃切除术。6年后,随访CT显示右肺门有一个可疑肿块,类似纵隔淋巴结。进一步的动态PET/CT图像显示,一个肿块位于右中间支气管,FDG摄取增加且Ki值相对较高,这可能意味着恶性的可能性。然而,对称的纵隔淋巴结FDG摄取强烈但Ki值相对较低,提示为良性病变。支气管镜活检的初始病理结果被认为可疑为转移性胃腺癌。然而,随后发现与中分化黏液表皮样癌一致,经手术(下叶双肺切除术+肺门和纵隔淋巴结清扫术)证实为无转移淋巴结的第二原发性癌症。F-FDG PET/CT在肿瘤病史患者的不确定结果随访中具有重要价值。此外,像Ki这样的动态定量参数在某些模棱两可的情况下可能有助于识别恶性肿瘤。