Carr Zyad J, Van De Louw Andry, Fehr Graham, Li Jialiu D, Kunselman Allen, Ruiz-Velasco Victor
Department of Anesthesiology & Perioperative Medicine, Penn State Milton S. Hershey Medical Center, H187, 500 University Dr., Hershey, PA, 17033, USA.
Division of Pulmonary & Critical Care Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA, 17033, USA.
BMC Res Notes. 2018 Jan 16;11(1):41. doi: 10.1186/s13104-018-3165-4.
Sepsis is a condition associated with a dysregulated inflammatory response to infection with significant morbidity. Recent advances have elucidated the vital role that the short chain fatty acid glycoprotein receptor 43 (FFA2/GPR43) plays in inflammatory and immunomodulatory pathways. We hypothesized that elevated whole blood GPR43 RNA expression would be associated with increased 30-day survival in patients admitted with sepsis. Patients (n = 93) admitted to the intensive care unit with the diagnosis of sepsis underwent quantitative real time PCR within 48 h of intensive care unit admission. Clinical and demographical parameters were retrospectively extracted from the chart and compared to quantitative measurements of GPR43 RNA expression.
Utilizing logistic regression, we found that the odds of mortality decreased for every one-unit increase in GPR43 RNA expression for patients that survived to 30 days [OR = 0.71; 95% CI (0.50, 0.99) p = 0.049]. Using linear regression, we determined that the increase in whole blood GPR43 expression was not associated with whole blood white cell count [r = 0.04; 95% CI (-0.16, 0.24); p = 0.70] or body mass index [r = - 0.07; 95% CI (- 0.23, 0.18); p = 0.81]. We conclude that the GPR43 receptor plays an integral role in survival during and after sepsis.
脓毒症是一种与感染后炎症反应失调相关的疾病，具有较高的发病率。最近的研究进展阐明了短链脂肪酸糖蛋白受体43（FFA2/GPR43）在炎症和免疫调节途径中所起的重要作用。我们假设，脓毒症患者全血GPR43 RNA表达升高与30天生存率增加相关。93例入住重症监护病房且诊断为脓毒症的患者在入住重症监护病房后48小时内接受了定量实时PCR检测。从病历中回顾性提取临床和人口统计学参数，并与GPR43 RNA表达的定量测量结果进行比较。
利用逻辑回归分析，我们发现，存活至30天的患者，GPR43 RNA表达每增加一个单位，死亡几率就会降低[比值比（OR）=0.71；95%置信区间（CI）（0.50，0.99）；P=0.049]。通过线性回归分析，我们确定全血GPR43表达的增加与全血白细胞计数[r=0.04；95%CI（-0.16，0.24）；P=0.70]或体重指数[r=-0.07；95%CI（-0.23，0.18）；P=0.81]无关。我们得出结论，GPR43受体在脓毒症期间及之后的生存中起着不可或缺的作用。
