Deakin Child Study Centre, School of Psychology, Deakin University, Geelong, Australia.
School of Psychology, Faculty of Health Sciences, Australian Catholic University, Melbourne, Australia.
Neurosci Biobehav Rev. 2018 Mar;86:77-84. doi: 10.1016/j.neubiorev.2018.01.002. Epub 2018 Jan 12.
Recent neuroimaging studies have reported atypical neural activation in children with Developmental Coordination Disorder (DCD) during tasks assessing manual dexterity. However, small sample sizes and subtle differences in task parameters have led to inconsistent findings, rendering interpretation difficult. The aim of the present meta-analysis was to quantitatively summarize this body of evidence using activation likelihood estimation (ALE) analysis to identify reliable regions of differential neural activation in children with DCD, compared to age-matched controls. Seven studies that adopted fMRI to compare children with and without DCD during manual performance were identified following a literature search. All were included in the ALE analysis. Compared to controls, children with DCD showed reduced activation during a manual dexterity task in the middle frontal gyrus, superior frontal gyrus, cerebellum, supramarginal gyrus, and inferior parietal lobule. Children with DCD showed greater activation in parts of the thalamus. Findings provide much needed clarification into the possible neural contributors to atypical manual dexterity in DCD and highlight the need for neuroimaging studies to include manual performance outcomes.
最近的神经影像学研究报告称，在评估手灵巧性的任务中，发育性协调障碍（DCD）儿童的神经激活存在异常。然而，由于样本量小和任务参数的细微差异，导致研究结果不一致，难以解释。本荟萃分析的目的是使用激活似然估计（ALE）分析对这一证据进行定量总结，以确定 DCD 儿童与年龄匹配的对照组之间神经激活的差异可靠区域。通过文献检索，确定了七项采用 fMRI 比较 DCD 儿童和无 DCD 儿童在手动表现期间的研究。所有研究均纳入 ALE 分析。与对照组相比，DCD 儿童在执行手灵巧性任务时，中额回、额上回、小脑、缘上回和顶下小叶的激活减少。DCD 儿童的丘脑部分区域的激活增加。这些发现为 DCD 中异常手灵巧性的可能神经贡献提供了急需的澄清，并强调需要进行包括手动性能结果在内的神经影像学研究。
