School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Trends Parasitol. 2018 May;34(5):388-403. doi: 10.1016/j.pt.2017.12.007. Epub 2018 Jan 12.
Parasitic helminths must establish chronic infections to complete their life cycle and therefore are potent modulators of multiple facets of host physiology. Parasitic helminths have coevolved with humans to become arguably master selectors of our immune system, whereby they have impacted on the selection of genes with beneficial mutations for both host and parasite. While helminth infections of humans are a significant health burden, studies have shown that helminths or helminth products can alter susceptibility to unrelated infectious or inflammatory diseases. This has generated interest in the use of helminth infections or molecules as therapeutics. In this review, we focus on the impact of helminth infections on pulmonary immunity, especially with regard to homeostatic lung function, pulmonary viral and bacterial (co)infections, and asthma.
寄生虫必须建立慢性感染才能完成其生命周期，因此它们是宿主生理多个方面的有效调节剂。寄生虫与人类共同进化，成为我们免疫系统的选择者，从而影响了对宿主和寄生虫都有益的基因突变的选择。虽然人类的寄生虫感染是一个重大的健康负担，但研究表明，寄生虫或寄生虫产物可以改变对无关的传染性或炎症性疾病的易感性。这引起了人们对使用寄生虫感染或分子作为治疗方法的兴趣。在这篇综述中，我们重点关注寄生虫感染对肺部免疫的影响，特别是在维持性肺功能、肺部病毒和细菌（共）感染以及哮喘方面。
