Farzanehfar Parisa
Florey Institute for Neuroscience & Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia; St Vincent's Hospital, Fitzroy, Victoria 3065, Australia.
Neurosci Res. 2018 Sep;134:1-9. doi: 10.1016/j.neures.2018.01.002. Epub 2018 Jan 12.
Parkinson's Disease (PD) motor symptoms are caused by loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc) of the midbrain. Dopamine cell replacement therapy (DA CRT), either by cell transplantation or endogenous repair, has been a potential treatment to replace dead cells and improve PD motor symptoms. Adult midbrain and striatum have been studied for many years to find evidence of neurogenesis. Although the literature is controversial, recent research has revived the possibility of neurogenesis here. This paper aims to review the process of neurogenesis (by focusing on gene expression patterns) in the adult midbrain/striatum and compare it with classical neurogenesis that occurs in developing midbrain, Sub Ventricular Zone (SVZ) and Sub Granular Zone (SGZ) of the adult brain.
帕金森病（PD）的运动症状是由中脑黑质致密部（SNc）中多巴胺（DA）神经元的丧失所引起的。通过细胞移植或内源性修复进行的多巴胺细胞替代疗法（DA CRT），一直是一种替代死亡细胞并改善PD运动症状的潜在治疗方法。为了找到神经发生的证据，人们已经对成年中脑和纹状体进行了多年研究。尽管文献存在争议，但最近的研究再次燃起了此处存在神经发生的可能性。本文旨在综述成年中脑/纹状体中的神经发生过程（通过关注基因表达模式），并将其与发育中的中脑、成年大脑的脑室下区（SVZ）和颗粒下区（SGZ）中发生的经典神经发生进行比较。
