Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Cancer Lett. 2018 Apr 10;419:20-26. doi: 10.1016/j.canlet.2018.01.033. Epub 2018 Jan 12.
Autophagy, a highly conserved catabolic process that involves the degradation and recycling of intracellular components in the lysosome, has emerged as a key process in the maintenance of T cell homeostasis and the regulation of T cell differentiation and function. In this review, we provide an overview of the mechanisms that mediate the regulation of autophagy in T cells and discuss different cellular processes that are under the control of autophagy in CD4 and CD8 T cells. A special emphasis is placed on the role that autophagy plays in the modulation of T cell metabolism and the consequences of this regulation on functional states and programs of differentiation in specific T cell populations.
自噬是一种高度保守的分解代谢过程，涉及溶酶体中细胞内成分的降解和再循环，它已成为维持 T 细胞动态平衡和调节 T 细胞分化和功能的关键过程。在这篇综述中，我们概述了调节 T 细胞自噬的机制，并讨论了自噬在 CD4 和 CD8 T 细胞中控制的不同细胞过程。特别强调了自噬在调节 T 细胞代谢中的作用，以及这种调节对特定 T 细胞群体的功能状态和分化程序的影响。
