性别和年龄对BUD13-ZNF259基因rs964184多态性与冠心病关联的影响。
Impact of gender and age on the association of the BUD13-ZNF259 rs964184 polymorphism with coronary heart disease.
作者信息
Xu Xiaofeng, Li Yirun, Huang Yi, Ye Huadan, Han Liyuan, Ji Huihui, Chen Xiaoyin, Wu Nan, Jiang Danjie, Xu Limin, Dai Dongjun, Duan Shiwei, Chen Xiaomin
机构信息
Key Laboratory of Ningbo First Hospital and Cardiovascular Center of Ningbo First Hospital, Ningbo University; Ningbo-China.
出版信息
Anatol J Cardiol. 2018 Jan;19(1):42-49. doi: 10.14744/AnatolJCardiol.2017.8002.
OBJECTIVE
Coronary heart disease (CHD) is the most common cause of death worldwide. This study aimed to validate the association of the rs964184 polymorphism with the CHD risk and included 874 CHD patients and 776 controls.
METHODS
rs964184 polymorphism genotyping was performed using Tm-shift polymerase chain reaction.
RESULTS
A strong association of the rs964184 polymorphism with CHD was found (genotype: X=14.365, p=0.001; allele: X=14.191, p=1.67x10; power=0.965). Gender analysis revealed a significant association only in males (genotype: X=12.387, p=0.002; allele: X=12.404, p=4.32x10; OR=1.467, 95% CI=1.185-1.817, power=0.945). Age and gender analyses revealed significant associations of the rs964184 polymorphism with CHD in males between the ages of 55 and 65 years (genotype: X=10.070, p=0.007; allele: X=10.077, p=0.002; OR=1.706, 95% CI=1.224-2.377, power=0.996) and in females older than 65 years (genotype: X=9.462, p=0.009; allele: X=9.560, p=0.002; OR=2.112, 95% CI=1.308-3.412, power=0.994). Further subgroup analysis suggested that rs964184 genotypes were significantly associated with TG levels in the patients (r=0.191, adjusted p=1.05x10) and controls (r=0.101, adjusted p=0.026).
CONCLUSION
Our results indicate that both gender and age have great impacts on the association of the rs964184 polymorphism with CHD among Chinese.
目的
冠心病（CHD）是全球最常见的死亡原因。本研究旨在验证rs964184多态性与冠心病风险的关联，纳入了874例冠心病患者和776例对照。
方法
采用Tm-shift聚合酶链反应进行rs964184多态性基因分型。
结果
发现rs964184多态性与冠心病存在强关联（基因型：X=14.365，p=0.001；等位基因：X=14.191，p=1.67×10；检验效能=0.965）。性别分析显示仅在男性中存在显著关联（基因型：X=12.387, p=0.002；等位基因：X=12.404, p=4.32×10；OR=1.467, 95%CI=1.185 - 1.817, 检验效能=0.945）。年龄和性别分析显示，rs964184多态性在55至65岁男性（基因型：X=10.070, p=0.007；等位基因：X=10.077, p=0.002；OR=1.706, 95%CI=1.224 - 2.377, 检验效能=0.996）以及65岁以上女性（基因型：X=9.462, p=0.009；等位基因：X=9.560, p=0.002；OR=2.112, 95%CI=1.308 - 3.412, 检验效能=0.994）中与冠心病存在显著关联。进一步的亚组分析表明，rs964184基因型与患者（r=0.191，校正p=1.05×10）和对照（r=0.101，校正p=0.026）的甘油三酯水平显著相关。
结论
我们的结果表明，性别和年龄对中国人群中rs964184多态性与冠心病的关联均有重大影响。
Zotero 插件