Alcala-Diaz Juan F, Arenas-de Larriva Antonio P, Torres-Peña Jose D, Rodriguez-Cantalejo Fernando, Rangel-Zuñiga Oriol A, Yubero-Serrano Elena M, Gutierrez-Mariscal Francisco M, Cardelo Magdalena P, Luque Raul M, Ordovas Jose M, Perez-Martinez Pablo, Delgado-Lista Javier, Lopez-Miranda Jose
Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofía University Hospital, University of Córdoba, Córdoba, Spain.
Centro de Investigación Biomédica en Red de Fisiología de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
Front Nutr. 2022 Jun 17;9:885256. doi: 10.3389/fnut.2022.885256. eCollection 2022.
rs964184 variant in the ZPR1 gene has been associated with blood lipids levels both in fasting and postprandial state and with the risk of myocardial infarction in high-risk cardiovascular patients. However, whether this association is modulated by diet has not been studied.
To investigate whether the type of diet (low-fat or Mediterranean diets) interacts with genetic variability at this loci to modulate fasting and postprandial lipids in coronary patients.
The genotype of the rs964184 polymorphism was determined in the Cordioprev Study population (NCT00924937). Fasting and Postprandial triglycerides were assessed before and after 3 years of dietary intervention with either a Mediterranean or a low-fat diet. Postprandial lipid assessment was done by a 4-h oral fat tolerance test (OFTT). Differences in triglycerides levels were identified using repeated-measures ANCOVA.
From 523 patients (85% males, mean age 59 years) that completed the OFTT at baseline and after 3 years of intervention and had complete genotype information, 125 of them were carriers of the risk allele G. At the start of the study, these patients showed a higher fasting and postprandial triglycerides (TG) plasma levels. After 3 years of dietary intervention, G-carriers following a Mediterranean Diet maintained higher fasting and postprandial triglycerides, while those on the low-fat diet reduced their postprandial triglycerides to similar values to the population without the G-allele.
After 3 years of dietary intervention, the altered postprandial triglyceride response induced by genetic variability in the rs964184 polymorphism of the ZPR1 gene can be modulated by a low-fat diet, better than by a Mediterranean diet, in patients with coronary artery disease.
ZPR1基因中的rs964184变异与空腹及餐后血脂水平相关，且与高危心血管疾病患者的心肌梗死风险有关。然而，这种关联是否受饮食调节尚未得到研究。
研究饮食类型（低脂或地中海饮食）是否与该基因位点的基因变异性相互作用，以调节冠心病患者的空腹和餐后血脂。
在Cordioprev研究人群（NCT00924937）中确定rs964184多态性的基因型。在采用地中海饮食或低脂饮食进行3年饮食干预前后，评估空腹和餐后甘油三酯水平。餐后血脂评估通过4小时口服脂肪耐量试验（OFTT）进行。使用重复测量协方差分析确定甘油三酯水平的差异。
在523例患者（85%为男性，平均年龄59岁）中，这些患者在基线和3年干预后完成了OFTT并拥有完整的基因型信息，其中125例为风险等位基因G的携带者。在研究开始时，这些患者的空腹和餐后甘油三酯（TG）血浆水平较高。经过3年的饮食干预后，采用地中海饮食的G等位基因携带者的空腹和餐后甘油三酯水平仍然较高，而低脂饮食组的餐后甘油三酯水平降至与无G等位基因人群相似的水平。
经过3年的饮食干预，对于冠心病患者，ZPR1基因rs964184多态性的基因变异所诱导的餐后甘油三酯反应改变，低脂饮食比地中海饮食能更好地对其进行调节。
