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How BMP-2 induces EMT and breast cancer stemness through Rb and CD44?

作者信息

Zhang Guanglin, Huang Peide, Chen Anan, He Weiyi, Li Zhen, Liu Ge, Wang Ju

机构信息

Institute of Biomedicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Centre of Genetic Medicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.

Section for Molecular Disease Biology, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen N, Denmark.

出版信息

Cell Death Dis. 2018 Jan 16;9(2):20. doi: 10.1038/s41419-017-0037-0.

DOI:10.1038/s41419-017-0037-0
PMID:29339728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5833867/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e1d/5833867/6a5125850749/41419_2017_37_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e1d/5833867/6a5125850749/41419_2017_37_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e1d/5833867/6a5125850749/41419_2017_37_Fig1_HTML.jpg

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本文引用的文献

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BMP-2 induces EMT and breast cancer stemness through Rb and CD44.骨形态发生蛋白-2通过视网膜母细胞瘤蛋白（Rb）和CD44诱导上皮-间质转化及乳腺癌干性。
Cell Death Discov. 2017 Jul 17;3:17039. doi: 10.1038/cddiscovery.2017.39. eCollection 2017.
2
RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer.RB缺失促成了MYC驱动的三阴性乳腺癌中的侵袭性肿瘤表型。
Cell Cycle. 2015;14(1):109-22. doi: 10.4161/15384101.2014.967118.
3
BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation.
对 bulk 和单细胞测序数据的综合分析揭示，EMP1/COL3A1 成纤维细胞有助于乳腺癌、前列腺癌和肾癌的骨转移过程。
Front Immunol. 2023 Dec 19;14:1313536. doi: 10.3389/fimmu.2023.1313536. eCollection 2023.
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BMP signaling in cancer stemness and differentiation.骨形态发生蛋白信号在癌症干性和分化中的作用
Cell Regen. 2023 Dec 5;12(1):37. doi: 10.1186/s13619-023-00181-8.
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NKX3.1 Expression Contributes to Epithelial-Mesenchymal Transition of Prostate Cancer Cells.NKX3.1表达促进前列腺癌细胞的上皮-间质转化。
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