肌醇耗竭、糖原合成酶激酶 3 抑制与双相情感障碍
Inositol depletion, GSK3 inhibition and bipolar disorder.
作者信息
Yu Wenxi, Greenberg Miriam L
机构信息
Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
出版信息
Future Neurol. 2016 May;11(2):135-148. doi: 10.2217/fnl-2016-0003. Epub 2016 Apr 26.
Abstract
Valproic acid and lithium are widely used to treat bipolar disorder, a severe illness characterized by cycles of mania and depression. However, their efficacy is limited, and treatment is often accompanied by serious side effects. The therapeutic mechanisms of these drugs are not understood, hampering the development of more effective treatments. Among the plethora of biochemical effects of the drugs, those that are common to both may be more related to therapeutic efficacy. Two common outcomes include inositol depletion and GSK3 inhibition, which have been proposed to explain the efficacy of both valproic acid and lithium. Here, we discuss the inositol depletion and GSK3 inhibition hypotheses, and introduce a unified model suggesting that inositol depletion and GSK3 inhibition are inter-related.
摘要
丙戊酸和锂被广泛用于治疗双相情感障碍，这是一种以躁狂和抑郁发作为特征的严重疾病。然而，它们的疗效有限，且治疗常常伴有严重的副作用。这些药物的治疗机制尚不清楚，这阻碍了更有效治疗方法的开发。在这些药物众多的生化效应中，两者共有的效应可能与治疗效果更相关。两个常见的结果包括肌醇耗竭和糖原合成酶激酶3（GSK3）抑制，有人提出这两种结果可以解释丙戊酸和锂的疗效。在此，我们讨论肌醇耗竭和GSK3抑制假说，并介绍一个统一模型，该模型表明肌醇耗竭和GSK3抑制是相互关联的。
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