Boven Lindsay C, Jiang Qin Li, Moss Heather E
University of Illinois College of Medicine, Chicago, Illinois, USA.
Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, Illinois, USA.
Neuroophthalmology. 2017 Apr 27;41(5):247-252. doi: 10.1080/01658107.2017.1305422. eCollection 2017 Oct.
High- and low-contrast visual acuity (HCVA, LCVA) are potential quantitative markers of neurological dysfunction in amyotrophic lateral sclerosis (ALS). The complex nature and duration of gold standard (GS) protocols precludes widespread use in neurology settings. This study compares simplified to GS visual acuity (VA) protocols. Monocular HCVA and LCVA were measured in ALS ( = 10) and control ( = 4) subjects using six protocols, varying by two chart and three refraction methods. Intraclass correlation coefficients between simplified and GS protocols ranged from 0.83 to 0.98 (HCVA, excellent agreement) and 0.56 to 0.75 (LCVA, moderate agreement). Differences between LCVA and GS protocols exceeded test-retest reliability. Simplified HCVA protocols using LCD (liquid crystal display) tablet charts and/or pinhole correction produced valid measurements. None of the modified LCVA testing protocols produced valid measurements.
高对比度和低对比度视力（HCVA、LCVA）是肌萎缩侧索硬化症（ALS）神经功能障碍的潜在定量指标。金标准（GS）检测方案的复杂性和时长妨碍了其在神经科环境中的广泛应用。本研究比较了简化视力（VA）检测方案和金标准检测方案。使用六种检测方案，通过两种视力表和三种验光方法，对10例ALS患者和4例对照受试者进行单眼HCVA和LCVA测量。简化检测方案与金标准检测方案之间的组内相关系数范围为0.83至0.98（HCVA，一致性极佳）和0.56至0.75（LCVA，一致性中等）。LCVA检测方案与金标准检测方案之间的差异超过了重测信度。使用液晶显示（LCD）平板视力表和/或针孔矫正的简化HCVA检测方案可得出有效的测量结果。改良后的LCVA检测方案均未得出有效的测量结果。
