Sun Weijing, Wang Qi, Guo Yingfang, Zhao Yifan, Wang Xinying, Zhang Zhenbiao, Deng Ganzhen, Guo Mengyao
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, People's Republic of China.
Oncotarget. 2017 Sep 8;8(67):110949-110964. doi: 10.18632/oncotarget.20740. eCollection 2017 Dec 19.
We studied the effects of selenium (Se) on the inflammatory response in ()-infected mastitis-model mice and mammary epithelial cells. In infected mice, Se elicited a dose-dependent decrease in mammary gland pathology that included inflammatory cell infiltration, disorganized acinar structure and mammary cell necrosis. Se decreased inflammation by increasing miR-146a and decreasing TLR2/6 as well as NF-κB and MAPK signaling pathways in mammary tissue from infected mice and mammary epithelial cells. A miR-146a inhibitor suppressed the anti-inflammatory effects of Se in infected mammary epithelial cells. Se, miR-146a and TLR2 were associated in determining the inflammatory response in mouse with infection-induced mastitis. Thus, Se inhibits pro-inflammatory responses in mammary tissues from -infected mice by inducing miR-146a.
我们研究了硒（Se）对感染（）性乳腺炎模型小鼠和乳腺上皮细胞炎症反应的影响。在感染的小鼠中，硒引起乳腺病理学的剂量依赖性降低，包括炎性细胞浸润、腺泡结构紊乱和乳腺细胞坏死。硒通过增加miR-146a、降低TLR2/6以及感染小鼠乳腺组织和乳腺上皮细胞中的NF-κB和MAPK信号通路来减轻炎症。miR-146a抑制剂抑制了硒在感染的乳腺上皮细胞中的抗炎作用。硒、miR-146a和TLR2在确定感染诱导的乳腺炎小鼠的炎症反应中相互关联。因此，硒通过诱导miR-146a抑制感染小鼠乳腺组织中的促炎反应。
