在中国乳腺癌患者中，3435TT和421CC基因型与更长的无进展生存期显著相关。
3435TT and 421CC genotypes were significantly associated with longer progression-free survival in Chinese breast cancer patients.
作者信息
Li Wanjun, Zhang Dan, Du Fen, Xing Xuemei, Wu Ying, Xiao Dong, Liang Ming, Fan Zhigang, Zhao Peng, Liu Tao, Li Guoyin
机构信息
Department of Pathology, Hanzhong 3201 Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Department of Oncology, Hanzhong 3201 Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi, China.
出版信息
Oncotarget. 2017 Oct 31;8(67):111041-111052. doi: 10.18632/oncotarget.22201. eCollection 2017 Dec 19.
OBJECTIVE
To investigate the distribution of C3435T and C421A gene polymorphisms in Chinese Han population and their influences on the susceptibility and prognosis of breast carcinoma.
METHODS
A total of 200 female subjects were enrolled in this study, comprising 100 breast cancer patients and 100 healthy controls. Carcinoma and para-carcinoma tissues were collected from the breast cancer patients, while peripheral blood was collected from healthy controls. Single nucleotide polymorphisms (SNPs) were detected by the Taqman method. Progression-free survival (PFS) and 5-year survival rate of the patients were calculated.
RESULTS
1 C3435T and 2 C421A polymorphisms were not associated with disease susceptibility and 5-year survival rate in the study population (>0.05). However, a high mutation rate of both 1 C3435T and 2 C421A (16% and 17%, respectively) was observed in breast cancer tissues. Patients with 1 3435TT genotype or 2 421CC genotype had longer PFS (<0.05).
CONCLUSION
1 3435TT and 2 421CC were significantly associated with longer PFS in Chinese breast cancer patients.
目的
研究中国汉族人群中C3435T和C421A基因多态性的分布及其对乳腺癌易感性和预后的影响。
方法
本研究共纳入200名女性受试者，其中包括100例乳腺癌患者和100名健康对照者。从乳腺癌患者中采集癌组织和癌旁组织，从健康对照者中采集外周血。采用Taqman方法检测单核苷酸多态性（SNP）。计算患者的无进展生存期（PFS）和5年生存率。
结果
在研究人群中，1个C3435T和2个C421A多态性与疾病易感性和5年生存率无关（>0.05）。然而，在乳腺癌组织中观察到1个C3435T和2个C421A的高突变率（分别为16%和17%）。具有1个3435TT基因型或2个421CC基因型的患者PFS更长（<0.05）。
结论
1个3435TT和2个421CC与中国乳腺癌患者更长的PFS显著相关。
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