Al-Eitan Laith N, Rababa'h Doaa M, Alghamdi Mansour A, Khasawneh Rame H
Department of Applied Biological Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan.
Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid 22110, Jordan.
J Oncol. 2019 Jul 17;2019:6425708. doi: 10.1155/2019/6425708. eCollection 2019.
Breast cancer pharmacogenetics is increasingly being explored due to chemotherapy resistance among certain classes of patients. The ATP binding cassette (ABC) transporter genes have been previously implicated in breast cancer progression and drug response. In the present study, single nucleotide polymorphisms (SNPs) from the , , , and genes were screened in breast cancer patients and healthy volunteers from the Jordanian-Arab population. Only the SNPs showed a significant association with BC in Jordanian-Arab patients, and the SNP rs2032582 exhibited a strong genotypic association with BC. With regard to the clinical characteristics of BC, the SNPs rs2273697 and rs717620 were found to be significantly associated with age at breast cancer diagnosis and breastfeeding status, while the SNP rs1045642 was significantly associated with age at breast cancer diagnosis. In terms of pathological characteristics, the SNP rs35628 and the SNP rs2032582 were significantly associated with tumor size, the SNP rs2273697 was significantly associated with estrogen receptor status, and the SNP rs2231142 was significantly associated with axillary lymph node status. In this current study, we assume that significant genetic variants within the ABC superfamily may increase the risk of breast cancer among Jordanian women. Furthermore, these variants might be responsible for worse BC prognosis.
由于某些类型患者存在化疗耐药性，乳腺癌药物遗传学正越来越多地被探索。ATP结合盒（ABC）转运蛋白基因先前已被认为与乳腺癌进展和药物反应有关。在本研究中，对约旦 - 阿拉伯人群的乳腺癌患者和健康志愿者进行了ABCB1、ABCC1、ABCC2和ABCG2基因的单核苷酸多态性（SNP）筛查。在约旦 - 阿拉伯患者中，只有ABCC2基因的SNP显示出与乳腺癌有显著关联，且SNP rs2032582与乳腺癌表现出强烈的基因型关联。关于乳腺癌的临床特征，发现ABCC2基因的SNP rs2273697和rs717620与乳腺癌诊断年龄和母乳喂养状况显著相关，而ABCB1基因的SNP rs1045642与乳腺癌诊断年龄显著相关。在病理特征方面，ABCC2基因的SNP rs35628和ABCG2基因的SNP rs2032582与肿瘤大小显著相关，ABCC2基因的SNP rs2273697与雌激素受体状态显著相关，ABCC1基因的SNP rs2231142与腋窝淋巴结状态显著相关。在本研究中，我们假设ABC超家族内的显著基因变异可能会增加约旦女性患乳腺癌的风险。此外，这些变异可能是乳腺癌预后较差的原因。
