Nelson S L, Bergman S A
Anesth Prog. 1985 Jul-Aug;32(4):151-6.
Single doses of the study drugs were evaluated for 12 hours by 201 out-patients reporting moderate or severe pain following oral surgery. The results of this double-blind study indicated that 50, 100, and 200 mg of etodolac as well as 650 mg of aspirin were significantly more effective than placebo. A dose-response relationship was found for the three doses of etodolac, which was significant for summed pain relief scores for up to 8 hours. In terms of total analgesic effect, etodolac 200 mg was significantly superior to placebo for 8 hours, while aspirin and the two lower doses of etodolac were similarly effective in the range of 3-6 hours postdrug. All doses showed a favorable onset of analgesia (½-1 hour). Etodolac 200 mg resulted in a duration of action which was approximately twice as long as aspirin's and also produced a peak pain relief which was significantly greater than the lower doses of etodolac and aspirin. All study medications were well tolerated with no reports of significant adverse side effects. No dose-related effects were observed with etodolac
201名口腔手术后出现中度或重度疼痛的门诊患者对研究药物进行了12小时的单剂量评估。这项双盲研究结果表明，50毫克、100毫克和200毫克依托度酸以及650毫克阿司匹林的疗效显著优于安慰剂。三种剂量的依托度酸呈现出剂量反应关系，在长达8小时的总疼痛缓解评分方面具有显著性。就总镇痛效果而言，200毫克依托度酸在8小时内显著优于安慰剂，而阿司匹林和两种较低剂量的依托度酸在用药后3至6小时内效果相似。所有剂量均显示出良好的镇痛起效时间（半小时至1小时）。200毫克依托度酸的作用持续时间约为阿司匹林的两倍，且产生的最大疼痛缓解程度显著高于较低剂量的依托度酸和阿司匹林。所有研究药物耐受性良好，未报告有显著不良副作用。未观察到依托度酸有剂量相关效应。
