Obana K, Naruse M, Inagami T, Brown A B, Naruse K, Kurimoto F, Sakurai H, Demura H, Shizume K
Biochem Biophys Res Commun. 1985 Nov 15;132(3):1088-94. doi: 10.1016/0006-291x(85)91918-7.
The effects of synthetic atrial natriuretic factor (ANF) were studied in superfused rat posterior pituitary gland. ANF (10(-6)M, 10(-10)M) significantly inhibited basal as well as KC1 (50 mM) or angiotensin II-stimulated immunoreactive arginine vasopressin secretion. The magnitude of inhibition was greater at 10(-6)M than at 10(-10)M. ANF also decreased cAMP secretion and increased cGMP secretion from the posterior pituitary. These results suggest that ANF directly acts on the posterior pituitary to inhibit arginine vasopressin secretion and that this effect is, at least, partly mediated by the changes in cyclic nucleotide production.
在体外灌流的大鼠垂体后叶中研究了合成心房钠尿肽（ANF）的作用。ANF（10⁻⁶M，10⁻¹⁰M）显著抑制基础状态以及氯化钾（50 mM）或血管紧张素II刺激的免疫反应性精氨酸加压素分泌。在10⁻⁶M时的抑制程度大于10⁻¹⁰M时。ANF还可减少垂体后叶中的环磷酸腺苷（cAMP）分泌并增加环磷酸鸟苷（cGMP）分泌。这些结果表明，ANF直接作用于垂体后叶以抑制精氨酸加压素分泌，并且这种作用至少部分是由环核苷酸产生的变化介导的。
