Hebden R A, Claybaugh J R, Hashiro G M
Department of Clinical Investigation, Tripler Army Medical Center, Hawaii 96859-5000.
Life Sci. 1992;51(3):195-202. doi: 10.1016/0024-3205(92)90075-z.
In the present study we compared the effects of Des Leu Angiotensin I (Des Leu AI) with Angiotensin II (AII) on the secretion of vasopressin (AVP) from the isolated hypothalamoneurohypophyseal system (HNS) and isolated posterior pituitary gland of the rat. Administration of 10(-6)M, 10(-5) M and 10(-4) M Des Leu AI was without significant effect on AVP secretion from the HNS. A similar phenomenon was seen in the posterior pituitary with 10(-6) M and 10(-5) M Des Leu AI, although 10(-4) M significantly increased AVP release. Administration of 10(-6) M AII was without significant effect in either preparation, although 10(-5) M and 10(-4) M AII caused significant dose-dependent increases in AVP secretion over control release that were similar in both the HNS and posterior pituitary gland. These results suggest that Des Leu AI is not a physiologically relevant stimulus of AVP secretion when restricted to this area of the rat brain. They are also consistent with the presence of receptors sensitive to AII in the pituitary gland of the rat.
在本研究中，我们比较了去亮氨酸血管紧张素I（Des Leu AI）和血管紧张素II（AII）对大鼠离体下丘脑神经垂体系统（HNS）和离体垂体后叶中血管加压素（AVP）分泌的影响。给予10(-6)M、10(-5)M和10(-4)M的Des Leu AI对HNS中AVP的分泌无显著影响。在垂体后叶中，10(-6)M和10(-5)M的Des Leu AI也出现类似现象，尽管10(-4)M显著增加了AVP的释放。给予10(-6)M的AII对两种制剂均无显著影响，尽管10(-5)M和10(-4)M的AII导致AVP分泌比对照释放有显著的剂量依赖性增加，这在HNS和垂体后叶中相似。这些结果表明，当局限于大鼠脑的这一区域时，Des Leu AI不是AVP分泌的生理相关刺激物。它们也与大鼠垂体中存在对AII敏感的受体一致。
