Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Neurochem Res. 2018 Mar;43(3):659-668. doi: 10.1007/s11064-018-2466-2. Epub 2018 Jan 16.
Neuroactive steroids such as progesterone, testosterone, and their derivatives have been widely studied for their neuroprotective roles in the nervous system. Autologous nerve transplantation is considered as the gold standard repair technique when primary suture is impossible; nevertheless, this method is far from ideal. In this study, we aimed to explore the impact of dihydrotestosterone (DHT), a 5α-reduced derivative of testosterone, on the recovery of peripheral nerve injury treated with autologous nerve transplantation. Sprague-Dawley rats were subjected to a 10-mm right side sciatic nerve reversed autologous nerve transplantation and randomly divided into groups that received DHT or DHT + flutamide (an androgen receptor blocker) daily for 8 weeks after operation. Our results demonstrated that DHT could speed up the rate of axonal regeneration and increase the expression of myelin protein zero (P0) in autograft reversal sciatic nerves. Thus, our study provided new insights into improving the prognosis of patients with long gap peripheral nerve defects.
神经活性甾体，如孕酮、睾丸酮及其衍生物，因其在神经系统中的神经保护作用而得到广泛研究。当初次缝合不可能时，自体神经移植被认为是黄金标准修复技术；然而，这种方法远非理想。在这项研究中，我们旨在探讨 5α-还原睾丸酮的衍生物二氢睾丸酮（DHT）对自体神经移植治疗外周神经损伤恢复的影响。SD 大鼠右侧坐骨神经 10mm 逆行自体神经移植，术后每天接受 DHT 或 DHT+氟他胺（雄激素受体阻滞剂）治疗 8 周，随机分组。我们的结果表明，DHT 可以加速轴突再生速度，并增加自体移植逆转坐骨神经中髓鞘蛋白零（P0）的表达。因此，我们的研究为改善长间隙周围神经缺损患者的预后提供了新的思路。
