Lee S T, Paraskevas F, Maeba J
Cell Immunol. 1985 Apr 15;92(1):64-73. doi: 10.1016/0008-8749(85)90065-6.
Immunogens activate in vivo within 3-6 hr after injection a new and hitherto unrecognized T-cell pathway which interferes with T-cell suppression, therefore called antisuppression. An important soluble mediator with antisuppressor activity is detected in the serum of immunized animals within 3-6 hr. The mediator represents a unique form of complexes of Ig and antigen. The antisuppressor function of the complexes does not represent a direct "neutralizing" effect of the complexes on the effector T suppressor cells. The antisuppressor complexes activate an Ly2+ T cell which, with the interaction of an Ly123+ T cell, blocks completely T-suppressor-cell function. The biological significance of the T antisuppressor pathway is discussed.
免疫原在注射后3 - 6小时内在体内激活一条新的、迄今未被认识的T细胞途径，该途径干扰T细胞抑制，因此称为抗抑制。在免疫动物的血清中3 - 6小时内可检测到一种具有抗抑制活性的重要可溶性介质。该介质代表Ig和抗原复合物的一种独特形式。复合物的抗抑制功能并不代表复合物对效应性T抑制细胞的直接“中和”作用。抗抑制复合物激活Ly2 + T细胞，该细胞与Ly123 + T细胞相互作用，完全阻断T抑制细胞的功能。文中讨论了T抗抑制途径的生物学意义。
