Paraskevas F, Lee S T, Maeba J, David C S
Cell Immunol. 1985 Apr 15;92(1):53-63. doi: 10.1016/0008-8749(85)90064-4.
It has previously been demonstrated that within 6 hr after immunogenic stimulation the serum of mice contains a unique form of immunogenic antigen which represents complexes of Ig and antigen. The complexes are known to be strongly cytophilic for Ly2+ Ia+ FcR+ T cells and markedly enhance the IgG response. Anti-I-A treatment of mice suppresses the IgG antibody response and results in the generation of antigen specific T suppressor cells (Ts). Furthermore, anti-I-A treatment blocks the induction of the complexes and abolishes the enhancing effect the complexes exert on the IgG antibody response. The 6-hr cytophilic complexes were shown to block the function of Ts and allow a normal IgG response to take place; therefore, they act as mediators of a novel T-cell pathway called antisuppression. The blocking of the induction of the antisuppressor complexes by anti-I-A antibody was at least in part due to an effect on T cells. In conclusion, products of genes of the I-A subregion of the MHC control the activation early after immunization of a T-cell pathway which is called antisuppression since its major function is interference with the expression of suppression. Its early induction (within 6 hr) suggests that antisuppression may play a pivotal role in determining between immunity and unresponsiveness.
先前已经证明，在免疫原性刺激后6小时内，小鼠血清中含有一种独特形式的免疫原性抗原，它代表Ig和抗原的复合物。已知这些复合物对Ly2 + Ia + FcR + T细胞具有很强的嗜细胞性，并显著增强IgG反应。用抗I - A处理小鼠会抑制IgG抗体反应，并导致抗原特异性T抑制细胞（Ts）的产生。此外，抗I - A处理会阻断复合物的诱导，并消除复合物对IgG抗体反应的增强作用。已证明6小时嗜细胞复合物可阻断Ts的功能，并使正常的IgG反应发生；因此，它们作为一种称为抗抑制的新型T细胞途径的介质发挥作用。抗I - A抗体对抗抑制复合物诱导的阻断至少部分是由于对T细胞的作用。总之，MHC的I - A亚区基因产物在免疫后早期控制一种T细胞途径的激活，该途径被称为抗抑制，因为其主要功能是干扰抑制的表达。其早期诱导（在6小时内）表明抗抑制可能在决定免疫和无反应性之间起关键作用。
