Paraskevas F, Lee S T, Maeba J
Cell Immunol. 1985 Apr 15;92(1):74-84. doi: 10.1016/0008-8749(85)90066-8.
Immunogenic stimuli rapidly induce a potent mediator with antisuppressor activity which represents complexes of Ig and antigen. The formation of the complexes depends on the interaction of two T cells both of which bear the Ly1 phenotype. The two T cells can be separated on the basis of their sensitivity to antilymphocytic serum and dependency on the presence of thymus. T cells bearing I region coded determinants are essential for the formation of the mediator.
免疫原性刺激迅速诱导出一种具有抗抑制活性的强效介质,它代表免疫球蛋白和抗原的复合物。这些复合物的形成取决于两个均带有Ly1表型的T细胞之间的相互作用。这两个T细胞可以根据它们对抗淋巴细胞血清的敏感性以及对胸腺存在的依赖性来分离。带有I区编码决定簇的T细胞对于介质的形成至关重要。