Khan Haroon, Amin Surriya, Patel Seema
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
Department of Botany, Islamia College University, Peshawar, Pakistan.
Life Sci. 2018 Mar 1;196:18-27. doi: 10.1016/j.lfs.2018.01.013. Epub 2018 Jan 16.
Current therapies in clinical practice face strong criticism regarding their efficacy, and side effects, which forced the neuro-researchers to discover novel agents with different mechanistic insights. Glycosides are naturally-occurring plant secondary metabolites with significant medicinal potential and clinical scope as antidepressant. The aim of this review is to focus on the antidepressant effects of glycosides in preclinical studies, with an emphasis on the possible mechanisms. The literature search revealed that only a few phytoglycosides have been evaluated for their relevance in depression alleviation. Through preclinical tests, it has come forth that the efficacy is mediated by the modulation of brain-derived neurotrophic factor (BDFN) in the hippocampus, that is known for promoting synaptic efficacy, neuronal connectivity and neuroplasticity. Thus, attempting the upregulation of BDNF expression by plant glycosides can be a novel therapeutic strategy for the treatment of depression. The outcome of this review can stimulate neuroscientists to evaluate plant-derived glycosides for the treatment of depression, as these structurally-complex and diverse molecules, might usher in a new paradigm in the treatment of depression, with a better efficacy and tolerability.
临床实践中的现有疗法在疗效和副作用方面面临强烈批评，这迫使神经研究人员去发现具有不同作用机制的新型药物。糖苷是天然存在的植物次生代谢产物，具有作为抗抑郁药的巨大药用潜力和临床应用范围。本综述的目的是关注糖苷在临床前研究中的抗抑郁作用，并着重探讨其可能的作用机制。文献检索发现，只有少数植物糖苷被评估了其在缓解抑郁方面的相关性。通过临床前测试发现，其疗效是通过调节海马体中的脑源性神经营养因子（BDNF）来介导的，BDNF以促进突触效能、神经元连接和神经可塑性而闻名。因此，尝试通过植物糖苷上调BDNF表达可能是治疗抑郁症的一种新的治疗策略。本综述的结果可以刺激神经科学家评估植物来源的糖苷用于治疗抑郁症，因为这些结构复杂且多样的分子可能会为抑郁症的治疗带来新的范式，具有更好的疗效和耐受性。
