Selzer P M, Murphy-Chutorian D, Ginsburg R, Wexler L
Invest Radiol. 1985 Nov;20(8):860-6. doi: 10.1097/00004424-198511000-00015.
The intrinsic optical properties of normal and diseased vascular tissues and their interaction with continuous wave (cw) and pulsed laser light were investigated to determine the optimal source for laser angioplasty. Both intima and atheromatous plaque demonstrated increasing spectral absorbance at shorter wavelengths (in the near ultraviolet). The relative differences in absorbance between diseased and nondiseased tissues were not sufficient to allow selective ablation of plaque. Atheromatous plaque appears more resistant than normal intima to damage by cw argon laser. The interaction of tissue with a high-power, pulsed ultraviolet laser showed a nonlinear response as pulse repetition rate and pulse energy were varied. From theoretical considerations and our experimental results, we propose that a pulsed ultraviolet laser with 50 millijoules of power per pulse and a repetition rate of 10 pps would be safer and more effective for recanalization than the cw argon laser.
研究了正常和病变血管组织的固有光学特性及其与连续波（cw）和脉冲激光的相互作用，以确定激光血管成形术的最佳光源。内膜和动脉粥样硬化斑块在较短波长（近紫外）处均表现出光谱吸光度增加。病变组织和非病变组织之间吸光度的相对差异不足以实现斑块的选择性消融。动脉粥样硬化斑块似乎比正常内膜对连续波氩激光的损伤更具抵抗力。当脉冲重复率和脉冲能量变化时，组织与高功率脉冲紫外激光的相互作用呈现非线性响应。基于理论考虑和我们的实验结果，我们提出，对于再通治疗，每脉冲功率为50毫焦耳、重复率为10次/秒的脉冲紫外激光比连续波氩激光更安全、更有效。
