Litvack F, Grundfest W S, Goldenberg T, Laudenslager J, Pacala T, Segalowitz J, Forrester J S
Department of Medicine (Cardiology), Cedars-Sinai Medical Center, UCLA School of Medicine 90048.
Lasers Surg Med. 1988;8(1):60-5. doi: 10.1002/lsm.1900080111.
Despite the theoretical advantages of submicrosecond pulsing for clinical laser angioplasty systems, the optimal laser parameters for clinical application are undefined. Further, the enormous peak powers achieved by submicrosecond pulses destroy available fiberoptics. We irradiated 797 segments of cadaver atherosclerotic aorta with nanosecond pulses at 266, 308, 355, 532, and 1064 nanometers. Effective cutting occurred at lower energy fluences in the ultraviolet than in the visible or infrared. For 308 nanometers, at any energy density, number of pulses to perforation was relatively independent of power density. Therefore, long-pulse ultraviolet wavelengths which could be transmitted through fiberoptics were identified as well suited for a clinical, submicrosecond pulsed laser angioplasty system.
尽管亚微秒脉冲对于临床激光血管成形术系统具有理论优势，但临床应用的最佳激光参数尚未确定。此外，亚微秒脉冲所达到的巨大峰值功率会损坏现有的光纤。我们用波长为266、308、355、532和1064纳米的纳秒脉冲照射了797段尸体动脉粥样硬化主动脉。在紫外线下，较低的能量通量就能实现有效切割，而在可见光或红外线下则不然。对于308纳米，在任何能量密度下，穿孔所需的脉冲数相对独立于功率密度。因此，能够通过光纤传输的长脉冲紫外波长被确定为非常适合临床亚微秒脉冲激光血管成形术系统。
