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实现对膜蛋白单体-二聚体测量的确定性控制。

Taking deterministic control of membrane protein monomer-dimer measurements.

机构信息

T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD

出版信息

J Gen Physiol. 2018 Feb 5;150(2):181-183. doi: 10.1085/jgp.201711913. Epub 2018 Jan 17.

DOI:10.1085/jgp.201711913
PMID:29343502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5805552/
Abstract

Fleming examines a new methodology for measuring the free energy of dimerization in lipid bilayers.

摘要

弗莱明研究了一种测量双层脂膜中二聚化自由能的新方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67cd/5805552/9049d80e481a/JGP_201711913_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67cd/5805552/9049d80e481a/JGP_201711913_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67cd/5805552/9049d80e481a/JGP_201711913_Fig1.jpg

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本文引用的文献

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A model-free method for measuring dimerization free energies of CLC-ec1 in lipid bilayers.一种用于测量脂质双层中 CLC-ec1 二聚化自由能的无模型方法。
J Gen Physiol. 2018 Feb 5;150(2):355-365. doi: 10.1085/jgp.201711893. Epub 2018 Jan 10.
2
Measuring Membrane Protein Dimerization Equilibrium in Lipid Bilayers by Single-Molecule Fluorescence Microscopy.利用单分子荧光显微镜测量脂质双分子层中膜蛋白二聚化平衡
Methods Enzymol. 2016;581:53-82. doi: 10.1016/bs.mie.2016.08.025. Epub 2016 Oct 11.
3
The dimerization equilibrium of a ClC Cl(-)/H(+) antiporter in lipid bilayers.
脂质双分子层中氯离子/氢离子反向转运体的二聚化平衡
Elife. 2016 Aug 3;5:e17438. doi: 10.7554/eLife.17438.
4
Design, function and structure of a monomeric ClC transporter.单体 ClC 转运蛋白的设计、功能和结构。
Nature. 2010 Dec 9;468(7325):844-7. doi: 10.1038/nature09556. Epub 2010 Nov 3.
5
Uncoupling and turnover in a Cl-/H+ exchange transporter.氯离子/氢离子交换转运体中的解偶联与周转
J Gen Physiol. 2007 Apr;129(4):317-29. doi: 10.1085/jgp.200709756.
6
The transmembrane domains of ErbB receptors do not dimerize strongly in micelles.表皮生长因子受体（ErbB）的跨膜结构域在微团中不会强烈二聚化。
J Mol Biol. 2005 Apr 8;347(4):759-72. doi: 10.1016/j.jmb.2005.01.059.
7
The GxxxG-containing transmembrane domain of the CCK4 oncogene does not encode preferential self-interactions.CCK4癌基因中含GxxxG的跨膜结构域并不编码优先的自我相互作用。
Biochemistry. 2005 Feb 8;44(5):1464-70. doi: 10.1021/bi048076l.
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Phosphatidylethanolamine-phosphatidylglycerol bilayer as a model of the inner bacterial membrane.磷脂酰乙醇胺 - 磷脂酰甘油双层膜作为细菌内膜的模型。
Biophys J. 2005 Feb;88(2):1091-103. doi: 10.1529/biophysj.104.048835. Epub 2004 Nov 19.
9
High-level expression, functional reconstitution, and quaternary structure of a prokaryotic ClC-type chloride channel.一种原核ClC型氯离子通道的高水平表达、功能重建及四级结构
J Gen Physiol. 1999 Nov;114(5):713-22. doi: 10.1085/jgp.114.5.713.