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一种改进的多电极螺旋袖带制作方法,用于选择性。

An improved method of crafting a multi-electrode spiral cuff for the selective.

机构信息

Center for Implantable Technology and Sensors, ITIS d. o. o. Ljubljana, Lepi pot 11, 1000, Ljubljana, Slovenia.

Institute of Pathophysiology, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia.

出版信息

Sci Rep. 2018 Jan 17;8(1):915. doi: 10.1038/s41598-018-19318-w.

Abstract

This article reviews an improved methodology and technology for crafting a multi-electrode spiral cuff for the selective activation of nerve fibres in particular superficial regions of a peripheral nerve. The analysis, structural and mechanical properties of the spot welds used for the interconnections between the stimulating electrodes and stainless-steel lead wires are presented. The cuff consisted of 33 platinum electrodes embedded within a self-curling 17-mm-long silicone spiral sheet with a nominal internal diameter of 2.5 mm. The weld was analyzed using scanning electron microscopy and nanohardness tests, while the interconnection was investigated using destructive load tests. The functionality of the cuff was tested in an isolated porcine vagus nerve. The results of the scanning electron microscopy show good alloying and none of the typical welding defects that occur between the wire and the platinum foil. The results of the destructive load tests show that the breaking loads were between 3.22 and 5 N. The results of the nanohardness testing show that the hardness of the weld was different for the particular sites on the weld sample. Finally, the results of the functional testing show that for different stimulation intensities both the compound action potential deflection and the shape are modulated.

摘要

本文回顾了一种改进的方法和技术,用于制作多电极螺旋袖带,以选择性地激活外周神经特别是浅层区域的神经纤维。本文介绍了用于刺激电极与不锈钢引线之间互连的点焊的分析、结构和机械性能。袖带由 33 个铂电极嵌入一个 17 毫米长的自卷曲硅酮螺旋片内,标称内径为 2.5 毫米。使用扫描电子显微镜和纳米硬度测试分析了焊点,使用破坏性负载测试研究了互连。在离体猪迷走神经中测试了袖带的功能。扫描电子显微镜的结果显示,在电线和铂箔之间没有出现典型的焊接缺陷,且发生了良好的合金化。破坏性负载测试的结果表明,断裂负载在 3.22 到 5N 之间。纳米硬度测试的结果表明,焊点上的特定部位的硬度不同。最后,功能测试的结果表明,对于不同的刺激强度,复合动作电位的挠度和形状都可以进行调制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab5a/5772407/2eeaf1650754/41598_2018_19318_Fig1_HTML.jpg

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