Wang Lili, Li Yan, Zhang Xia, Li Hongxia
Department III of Oncology, Binzhou City Central Hospital, Binzhou, Shandong 251700, P.R. China.
Department of Hospital Infection-Control, Binzhou City Central Hospital, Binzhou, Shandong 251700, P.R. China.
Oncol Lett. 2017 Dec;14(6):7379-7383. doi: 10.3892/ol.2017.7144. Epub 2017 Oct 5.
The present study was planned to investigate the characteristics of nosocomial infection and its effects on the survival in advanced non-small cell lung cancer (NSCLC) patients. Retrospective analysis was performed for the 169 chemotherapy patients with NSCLC and nosocomial infection during hospitalization in Binzhou City Central Hospital from March, 2013 to January, 2015. In addition, 170 patients without nosocomial infection were also involved as a control group. The distribution of major drug resistance of Gram-negative (G) and Gram-positive (G) were analyzed. The survival conditions of the patients were analyzed according to the nosocomial infection occurrence. The risk factors of nosocomial infection in patients with NSCLC were analyzed by univariate and multivariate logistic analysis. The percentage of G infection was 45.6% while G infection was 54.4%. Nosocomial infections were most common in respiratory system. The median survival time of the observation group was shorter than that of the control group (P<0.05). G infection was the most common type of infection in nosocomial infection of the patients with NSCLC. The occurrence of infection seriously affected the survival time of patients. Attention is required to the patients older than 60 years undergoing treatment with glucocorticoids as well as immunosuppressive agents.
本研究旨在调查晚期非小细胞肺癌（NSCLC）患者医院感染的特征及其对生存的影响。对2013年3月至2015年1月在滨州市中心医院住院期间发生医院感染的169例NSCLC化疗患者进行回顾性分析。此外，选取170例未发生医院感染的患者作为对照组。分析革兰阴性（G）菌和革兰阳性（G）菌主要耐药情况的分布。根据医院感染的发生情况分析患者的生存状况。通过单因素和多因素逻辑回归分析NSCLC患者医院感染的危险因素。G菌感染占45.6%，G菌感染占54.4%。医院感染最常见于呼吸系统。观察组的中位生存时间短于对照组（P<0.05）。G菌感染是NSCLC患者医院感染中最常见的感染类型。感染的发生严重影响患者的生存时间。对于年龄大于60岁且接受糖皮质激素及免疫抑制剂治疗的患者需予以关注。
