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长链非编码RNA lncTCF7激活Wnt/β-连环蛋白通路以促进结直肠癌的转移和侵袭。

Long non-coding RNA lncTCF7 activates the Wnt/β-catenin pathway to promote metastasis and invasion in colorectal cancer.

作者信息

Li Tengyu, Zhu Jing, Wang Xin, Chen Guowei, Sun Lie, Zuo Shuai, Zhang Junling, Chen Shanwen, Ma Ju, Yao Zihao, Zheng Youwen, Chen Zeyang, Liu Yucun, Wang Pengyuan

机构信息

Division of General Surgery, Peking University First Hospital, Peking University, Beijing 100034, P.R. China.

出版信息

Oncol Lett. 2017 Dec;14(6):7384-7390. doi: 10.3892/ol.2017.7154. Epub 2017 Oct 9.

DOI:10.3892/ol.2017.7154
PMID:29344178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5755009/
Abstract

Long non-coding RNA (Lnc)TCF7 is a novel lncRNA that is involved in tumorigenesis. Previous studies have revealed that lncTCF7 serves an essential role in maintaining cancer stem cell self-renewal; however, the functions of lncTCF7 in colorectal cancer (CRC) remain unknown. Therefore, the present study aimed to investigate the role of lncTCF7 in CRC. LncTCF7 was upregulated in 52/58 CRC tissues, and its expression correlated with tumor size, lymph metastasis and tumor-node-metastasis stage in CRC. Knocking down lncTCF7 in colon cancer cell lines decreased cell proliferation, migration and invasion, while lncTCF7 overexpression showed opposite changes. In addition, lncTCF7 promoted cell proliferation . LncTCF7 activated the Wnt/β-catenin signaling pathway, which is essential for cancer development. Survival analysis revealed that patients with higher expression of lncTCF7 had significantly worse prognosis compared with patients with low expression. These findings indicate that lncTCF7 regulates CRC progression and support the notion of lncTCF7 as a CRC prognostic marker.

摘要

长链非编码RNA（Lnc）TCF7是一种参与肿瘤发生的新型长链非编码RNA。先前的研究表明，lncTCF7在维持癌症干细胞自我更新中起重要作用；然而，lncTCF7在结直肠癌（CRC）中的功能仍不清楚。因此，本研究旨在探讨lncTCF7在CRC中的作用。lncTCF7在52/58例CRC组织中上调，其表达与CRC的肿瘤大小、淋巴结转移及肿瘤-淋巴结-转移分期相关。在结肠癌细胞系中敲低lncTCF7可降低细胞增殖、迁移和侵袭，而lncTCF7过表达则表现出相反的变化。此外，lncTCF7促进细胞增殖。lncTCF7激活了对癌症发展至关重要的Wnt/β-连环蛋白信号通路。生存分析显示，lncTCF7高表达患者的预后明显比低表达患者差。这些发现表明lncTCF7调节CRC进展，并支持lncTCF7作为CRC预后标志物的观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/57b072f20f4e/ol-14-06-7384-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/314f1461413b/ol-14-06-7384-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/1956c92764c8/ol-14-06-7384-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/cdca5a54eaa5/ol-14-06-7384-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/33b4b6c3e921/ol-14-06-7384-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/b43e7e7db899/ol-14-06-7384-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/57b072f20f4e/ol-14-06-7384-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/314f1461413b/ol-14-06-7384-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/1956c92764c8/ol-14-06-7384-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/cdca5a54eaa5/ol-14-06-7384-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/33b4b6c3e921/ol-14-06-7384-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/b43e7e7db899/ol-14-06-7384-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b69/5755009/57b072f20f4e/ol-14-06-7384-g05.jpg

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