Chao Hsiao-Mei, Wang Teh-Wei, Chern Edward, Hsu Shan-Hui
Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.
niChe Lab for Stem Cell and Regenerative Medicine, Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan.
World J Gastrointest Oncol. 2022 Apr 15;14(4):748-764. doi: 10.4251/wjgo.v14.i4.748.
The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and metastasis, have been indicated to be responsible for the poor prognosis of patients with colon cancers. The epigenetic regulatory network plays a crucial role in CSC properties. Regulatory non-coding RNA (ncRNA), including microRNAs, long noncoding RNAs, and circular RNAs, have an important influence on cell physiopathology. They modulate cells by regulating gene expression in different ways. This review discusses the basic characteristics and the physiological functions of colorectal cancer (CRC) stem cells. Elucidation of these ncRNAs will help us understand the pathological mechanism of CRC progression, and they could become a new target for cancer treatment.
癌症干细胞（CSCs）的特性，如自我更新、耐药性和转移，已被表明与结肠癌患者的不良预后有关。表观遗传调控网络在CSC特性中起着关键作用。调控性非编码RNA（ncRNA），包括微小RNA、长链非编码RNA和环状RNA，对细胞生理病理具有重要影响。它们通过不同方式调节基因表达来调控细胞。本综述讨论了结直肠癌（CRC）干细胞的基本特征和生理功能。阐明这些ncRNA将有助于我们理解CRC进展的病理机制，并且它们可能成为癌症治疗的新靶点。
