Tomas Cara, Finkelmeyer Andreas, Hodgson Tim, MacLachlan Laura, MacGowan Guy A, Blamire Andrew M, Newton Julia L
Institute of Cellular Medicine, Newcastle University, Newcastle, Newcastle upon Tyne, UK.
Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle, Newcastle upon Tyne, UK.
Open Heart. 2017 Dec 27;4(2):e000697. doi: 10.1136/openhrt-2017-000697. eCollection 2017.
To explore levels of the brain natriuretic peptide (BNP) and how these associate with the cardiac abnormalities recently identified in chronic fatigue syndrome (CFS).
Cardiac magnetic resonance examinations were performed using 3T Philips Intera Achieva scanner (Best, Netherlands) in CFS (Fukuda) participants and sedentary controls matched group wise for age and sex. BNP was also measured by using an enzyme immunoassay in plasma from 42 patients with CFS and 10 controls.
BNP levels were significantly higher in the CFS cohort compared with the matched controls (P=0.013). When we compared cardiac volumes (end-diastolic and end-systolic) between those with high BNP levels (BNP >400 pg/mL) and low BNP (<400 pg/mL), there were significantly lower cardiac volumes in those with the higher BNP levels in both end-systolic and end-diastolic volumes (P=0.05). There were no relationships between fatigue severity, length of disease and BNP levels (P=0.2) suggesting that our findings are unlikely to be related to deconditioning.
This study confirms an association between reduced cardiac volumes and BNP in CFS. Lack of relationship between length of disease suggests that findings are not secondary to deconditioning. Further studies are needed to explore the utility of BNP to act as a stratification paradigm in CFS that directs targeted treatments.
Registered with NIHR Portfolio CLRN ID 97805.
探讨脑钠肽（BNP）水平及其与慢性疲劳综合征（CFS）中最近发现的心脏异常之间的关联。
使用3T飞利浦Intera Achieva扫描仪（荷兰贝斯特）对符合CFS（福田标准）的参与者以及按年龄和性别进行组间匹配的久坐不动的对照组进行心脏磁共振检查。还采用酶免疫分析法对42例CFS患者和10例对照者的血浆BNP进行了检测。
与匹配的对照组相比，CFS队列中的BNP水平显著更高（P = 0.013）。当我们比较高BNP水平（BNP＞400 pg/mL）和低BNP水平（＜400 pg/mL）者的心脏容积（舒张末期和收缩末期）时，高BNP水平者的收缩末期和舒张末期容积均显著更低（P = 0.05）。疲劳严重程度、病程长短与BNP水平之间无相关性（P = 0.2），这表明我们的研究结果不太可能与失适应有关。
本研究证实了CFS患者心脏容积减小与BNP之间存在关联。病程长短与BNP水平缺乏相关性表明该结果并非由失适应所致。需要进一步研究以探讨BNP作为CFS分层范例指导靶向治疗的效用。
在NIHR Portfolio CLRN ID 97805注册。
